Ortho-mcneil Pharmaceutical Corp.

Covx Technologies Ireland Limited

Pfizer Healthcare Ireland

Alice Lee

J Guy Breitenbucher

Liming Huang

Kelly J McClure

Frank Urban Axe

David Tumelty

Abhijit Suresh Bhat

Kristen L Arienti

Olivier Alexandre Laurent

Richard Ryan Preston

Wei Hong Yu

Curt William Bradshaw

Anna Maria Tempczyk-Russell

Lauren Diane Wood

Anna Tempczyk-russell

Kelly J Mcclure

Frank U Axe

The present invention relates to a polypeptide comprising 7 &#x3b2;-strands A, B, C, D, E, F, and G sequentially connected together by connecting chains of amino acids, and a first &#x3b1;-helix sequentially located on the EF chain between &#x3b2;-strands E and F, wherein the &#x3b2;-strands are arranged so as to form a first &#x3b2;-sheet comprising &#x3b2;-strands A, B, D, and E, and a second &#x3b2;-sheet comprising &#x3b2;-strands C, F and G, said first and second &#x3b2;-sheets being covalently bonded together so as to form a first Ig domain; wherein the EF chain between &#x3b2;-strands E and F comprises the sequence X-X-X-X-KH(SEQ ID NO:98), and X, Xand Xare each independently any amino acid residue, characterized in that Xis selected from the group consisting of A, G, I, V, L, R, S, T, Q, P, N, M, H, W, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, and prodrugs thereof.

Mutant antibodies and conjugation thereof

The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CL&#x3ba;) comprising Kaccording to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety. The invention further provides specific MAC compounds and compositions of the invention.

Multifunctional antibody conjugates

2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.

Substituted benzimidazoles and imidazo-[4,5]-pyridines

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Alice Lee