Rhone-poulenc Rorer S.a.

Aventis Pharma S.a.

Alice Kanazawa

Jean-Noel Denis

Andrew-Elliot Greene

Novel carboxylic acids of formula (VI), useful for preparing taxane derivatives of general formula (I) by esterifying protected baccatine (III) or protected diacetyl baccatin (III) with an acid of general formula (II). The products of general formula (I) are particularly useful for preparing taxol, Taxotere and analogs thereof having anti-tumor properties.

Carboxylic acids for synthesis of taxane derivatives

A .beta.-phenylisoserine derivative of general formula (I): ##STR1## in the form of a salt or an ester, in which Ar represent an aryl radical, R represents a phenyl or naphthyl or a O--R.sub.1 radical and G.sub.1 represents --CH.sub.2 --Ph radical; and a method of using the same for making taxane derivatives.

Method for the stereo-selective preparation of a derivative of

Process for the preparation of a 1,3-oxazolidine-5-carboxylic acid

Process for the stereoselective preparation of a .beta.-phenylisoserine

Method for preparing taxane derivatives

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Grenoble, France

Alice Kanazawa