University of Iowa Research Foundation

The Johns Hopkins University

United States of America, As Represented by the Secretary of Agriculture

The University of Nottingham

Aliasger Karimjee Salem

Liu Hong

Brad A Amendt

Thad Sharp

George J Weiner

Ned B Bowden

Satheesh Elangovan

Sean M Geary

Kam W Leong

Peter C Searson

Douglas R Spitz, Jr

Kevin Morris Shakesheff

Mark E Anderson

Jun Woo Yoo

Michael Kormann

David P Alt

Caitlin Lemke

Yogita Krishnamachari

Gustavo Avila Ortiz

Denison J Kuruvilla

Sheetal Reginald R D'mello

Mei-ling A Joiner

Amaraporn Wongrakpanich

Anh-Vu T Do

Frederick E Domann

Duane D Hall

Behnoush Khorsand-Sourkohi

Olha M Koval

Jennifer H Wilson-Welder

Amani Makkouk

Emad I Wafa

Leela Raghava Jaidev Chakka

Vijaya B Joshi

Syed M A Muqsit Hashmi

A Descemet Membrane Endothelial Keratoplasty (DMEK) holder for placement within a vial for supporting a corneal tissue inserter is provided. The DMEK holder includes a top and an opposite bottom, at least one support member extending between the top and the bottom, with a bottom portion of the at least one support member sized and shaped to fit against a bottom inner surface of the vial to thereby support the corneal tissue inserter within the vial, and a first annular member having an opening sized and shaped such that a bottom end of the corneal tissue inserter is insertable through the opening and the first annular member separates the corneal tissue inserter from an inner surface of the vial and positions the corneal tissue inserter within the vial away from inner surfaces of the vial to thereby improve retrieval of the corneal tissue inserter by a surgeon.

Preloaded DMEK holder

A composition comprising particles formed of poly(diaminosulfide) and one or more leptospiral antigens, and methods of making and using the composition, are provided.

Poly(diaminosulfide) particle-based vaccine

In certain embodiments, the present invention provides the use of microRNA (miR)-200a to inhibit ossification and bone formation.

MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration

Compositions and methods to prevent, inhibit or treat aveolar or periodontal bone loss, enhance bone regeneration, prevent, inhibit or treat peri-implantitis or periodontitis, e.g., periodontitis or peri-implantitis associated with bone loss, or to prevent, inhibit or treat osteoarthritis are provided.

Methods to prevent or treat periodontitis or peri-implantitis

The present disclosure provides compositions and methods useful for tissue engineering including a composition having chemically modified RNA (cmRNA) encapsulated in or complexed with a non-viral delivery vehicle and a biocompatible, bioresorbable scaffold and methods of using the composition to regenerate, for example, bone tissue.

RNA based biomaterial for tissue engineering applications

Disclosed are compositions, kits, and methods for treating cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat a tumor in a subject in situ. The compositions, kits, and methods comprise or utilize cytotoxic particles, immune checkpoint inhibitors, and/or T-cell stimulatory agents.

Methods for treating tumors in situ including intratumor injection of cytotoxic particles and immune checkpoint blockade therapy

In certain embodiments, the present invention provides the use of microRNA (miR)-200a and/or miR-200c to inhibit ossification and bone formation. In certain embodiments, the present invention provides the use of miR-200a inhibitor to stimulate bone regeneration.

The present invention provides three-component compositions comprising microparticles, a tumor antigen, a first immune adjuvant, and a second immune adjuvant. Also provided are chemo-immunotherapeutic compositions comprising microparticles, a chemotherapeutic agent, and an immune adjuvant.

Biodegradable particulate formulations

The present invention provides methods for preparing polysulfenamides having a repeating unit of formula (4): wherein Ris selected from the group consisting of alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, hydroxyalkyl, ether, cycloether, aryl, heteroaryl, arylalkyl, heteroarylalkyl, hydroxyaryl, arylether, cycloalkyl, heterocycloalkyl, hydroxycycloalkyl, halocycloalkyl, and aminocycloalkyl. Each of R, Rand Rare independently selected from the group consisting of alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, hydroxyalkyl, ether, cycloether, aryl, heteroaryl, arylalkyl, heteroarylalkyl, hydroxyaryl, arylether, cycloalkyl, heterocycloalkyl, hydroxycycloalkyl, halocycloalkyl, and aminocycloalkyl. Microparticles comprising polysulfenamides can be used as delivery vehicles for a variety of biological applications.

Biodegradable polymers with sulfenamide bonds for drug delivery applications

Disclosed are compositions and methods for treating or preventing diseases or disorders associated with mitochondrial CaMKII activity.

Mitochondrial-targeted cationic nanoparticles comprising CaMKII inhibitors and uses thereof for treating and preventing diseases and disorders associated with CaMKII activity

An open porous matrix of particulate material for in vivo use in or on a target tissue in medicine, the matrix comprising particles cross-linked with one another so as to define pores there between and uses therefor are described.

Porous matrix comprising cross-linked particles

This invention is predicated on the present applicants' discovery that nanostructures comprising discrete regions of different composition can be used to deliver to a biological cell a desired combination of molecules in close proximity. Different molecules can be selectively bonded to discrete regions of different composition in sufficiently close physical relationship to enhance delivery or effectiveness within the cell. The preferred nanostructures are multicomponent nanorods. Important applications include delivery of missing DNA sequences for gene therapy and delivery of antigens or DNA encoding antigens for vaccination.

Methods and products for delivering biological molecules to cells using multicomponent nanostructures

Growing community of inventors

Coralville, IA, United States of America

Aliasger Karimjee Salem