The Brigham and Women's Hospital, Inc.

The Charles Stark Draper Laboratory, Inc.

Ali Tavakkoli

Jeffrey Michael Karp

Yuhan Lee

Tarawatie E Deelman

William Whitcomb McFarland

Christopher V Trainor

Jeffrey Ishizuka

Daniel F Traviglia

This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.

Water-activated mucoadhesive compositions to reduce intestinal absorption of nutrients

This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compounds for treating disorders requiring a modulation of certain nutrients to the body including diabetes type II and clinical obesity.

Compounds to modulate intestinal absorption of nutrients

The systems and methods described herein related generally to a device that enables the directional control of flow through an anatomical tract of the body. More particularly, the device described herein includes a valve from a plurality of projections. In some implementations, the projections are configured as flaps, posts, or any combination thereof. In some implementations, the device is implanted into a patient's esophagus to prevent gastroesophageal reflux disease. The plurality of projections allow flow into a patient's stomach while substantially preventing a backflow of undesired fluids from the patient's stomach to the patient's esophagus.

Implantable device for directional control of flow within the anatomic tracts of the body

Growing community of inventors

Boston, MA, United States of America

Ali Tavakkoli