Ampac Fine Chemicals LLC

Ali Suleman

Aslam A Malik

Francis Hempenstall

Nicholas Duda

Brian R Morgan

Olivier Dapremont

Patrick Berget

William Dubay

Jeffrey D Butler

Novel methods and systems for producing a substantially pure d-threo stereoisomer of methylphenidate or a salt thereof are provided. In particular, methods and systems for producing d-threo-methylphenidate hydrochloride in pure stereoisomeric form from d-threo-ritalinic acid hydrochloride using diazomethane are described. The described methods can be performed on a large scale, and thus provide d-threo methylphenidate or a salt thereof, and particularly the hydrochloride salt of d-threo-methylphenidate, in stereoisomerically pure form and in large quantities from a single batch reaction. Also described are novel compositions of d-threo methylphenidate hydrochloride.

Methods for preparing d-threo-methylphenidate using diazomethane, and compositions thereof

Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof

Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds from an isomerically pure starting material are described. In particular, methods of preparing a 3-(1-(dimethylamino)-2-methylpentane-3-yl)phenol as a substantially optically pure (R,R) stereoisomer are described. Using a method of the present invention, only the (R,R) and (S,S) stereoisomers of the target compound are produced, increasing the yield and stereoselectivity of the desired (R,R) stereoisomer.

Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds

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Folsom, CA, United States of America

Ali Suleman