Bayer Aktiengesellschaft

Bayer Cropscience Ag

Ali Sanli

Martin Littmann

Taraneh Farida

Kyra Larissa Pabst

Albert Schnatterer

Juergen Ludwig

Daniel Hartmann

Jürgen Ludwig

The present invention relates to a novel, one-stage method for preparing and isolating 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide (isotianil), which has microbicidal and plant-fortifying (host defence inducer) properties. In the method according to the invention, the amount of waste from the production process (e.g. solvent) is significantly reduced. The product is provided in high yield and purity (minimal amount of by-products and impurities). Compared to existing preparation methods, the method according to the invention has the advantage of low corrosiveness and high yield and high selectivity.

Method for producing 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide

The present invention relates to a novel process for preparing and isolating 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide (Isotianil), which can be used as an active compound with microbicidal properties, wherein the amount of waste materials&#x2014;e.g. solvents and diluents&#x2014;is significantly reduced and the process meets the requirements of industrial scale production, in particular that it provides the product in high yield, high purity, i.e. minimum amount of by-products and impurities, and can be carried out with tolerable corrosivity in industrial scale metal, in particular stainless steel, vessels or Cr&#x2014;Ni&#x2014;Mo alloy pressure filters or centrifuges.

Process for preparing 3,4-dichloro-n-(2-cyanophenyl)-5-isothiazolecarboxamide

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Leverkusen, Germany

Ali Sanli