Sanofi

Elf Sanofi

Laboratories Care System

Ali Salhi

Bernard Labeeuw

Dominique Olliero

Gilles Roche

Vincenzo Proietto

Didier Rase

The present invention relates to novel cephalosporin derivatives with improved pharmacokinetics, corresponding to the formula: ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3 represent a hydrogen atom, or R.sub.1 and R.sub.2 represent a hydrogen atom or a methyl group and R.sub.3 represents a carboxyl group, or ##STR2## form a cyclobutyl group and R.sub.3 represents a carboxyl group; and A and B are different and occupy the meta and para positions of the benzene ring, one representing a hydroxyl group and the other being selected from the groups ##STR3## and --NH--SO.sub.2 --Alk--NH.sub.2 in which Alk denotes a C.sub.2 -C.sub.4 lower alkylene group and also to the pharmaceutically acceptable salts and esters of the said derivatives. It further relates to a process for the preparation of such cephalosporins and to pharmaceutical compositions in which they are present.

Aromatic acid intermediates

The present invention relates to a topical antimicrobial composition, comprising microcapsules containing an antimicrobial agent, wherein the wall of the said microcapsules is formed of collagen and glycosaminoglycan cross-linked by means of a cross-linking agent. The antimicrobial composition of the invention may be used in body deodorants and in topical disinfectants.

Topical antimicrobial composition and uses

Cephalosporin derivatives and pharmaceutical compositions in which they

The invention relates to N-substituted lauramides. These compounds have the formula ##STR1## in which R.sub.1 is a benzyl group and R.sub.2 is an alkyl having from 1 to 4 carbon atoms, or R.sub.1 and R.sub.2 form a 4-benzylpiperidino group with the nitrogen atom to which they are bonded, and n=2 to 6, or one of its salts with organic or mineral acids. Application: Preparation of compositions for antiseptic or antimicrobial use, or disinfectants and preservatives, especially in the sectors of pharmacy, cosmetology or agri-foodstuffs.

N-substituted lauramides, their preparation and compositions in which

The present invention relates to derivatives of the cephalosporin family, of formula: ##STR1## in which: X is an oxygen atom or a sulfur atom

Cephalosporin derivatives, and their application as antibiotics

The compounds according to the invention correspond to the formula: ##STR1## in which: The COOA group at the 4 position is an acid radical, or an alkaline or alkaline-earth salt, or an amino acid or amine salt, for example triethylamine or ethanolamines, or an easily hydrolyzable or metabolically labile and pharmaceutically acceptable ester radical.

Antibiotic compounds derived from cephalosporins, process for their

The present invention relates to new cephalosporins of general formula ##STR1## in which R.sub.1 =R.sub.2 =CH.sub.3 or R.sub.1 and R.sub.2 together form a 1,3-propylene group, A is H, a cation, an ester or a hemiacetal, and R.sub.3 is a heterocycle comprising five or six atoms including at least one atom in the ring of nitrogen. It also relates to a process for preparing these cephalosporins and to the drugs containing them.

Derivatives of cephalosporins substituted in 3 position by a thiomethyl

The present invention relates to cephalosporins of general formula: ##STR1## in which: R.sub.1 is H or CH.sub.3, R.sub.2 is CH.sub.3, or R.sub.1 and R.sub.2 taken together form a 1,3-propylene group,

Derivatives of pyridinium thiomethyl cephalosporins

The present invention relates to cephalosporins having the formula: ##STR1## in which COOA is an acidic radical, salt or ester, and R.sub.1 represents a group: ##STR2## in which R.sub.A and R.sub.B are H or alkyl or together form a cycloalkyl with the carbon to which they are bonded, R.sub.2 and R.sub.3 are H, alkyl or alkenyl, R.sub.4 and R.sub.5 are H, alkyl or alkenyl or together form a ring to the nitrogen atom with which they are bonded. This invention also relates to a process for the preparation of these compounds and to drugs containing them.

Derivatives of cephalosporins, their process of separation and

The present invention relates to derivatives of the family of cephalosporins, of formula: ##STR1## in which ##STR2## is an acid, a salt or an ester of this acid, R.sub.1 is a group of form ##STR3## in which R.sub.A and R.sub.B are H or alkyl or form a saturated cyclobutyl or cyclopentyl ring and R.sub.C is H or COOH, R.sub.2 is a thiazolium salt or a OCOCH.sub.2 R.sub.D group in which R.sub.D is a 1,3-thiazol-4-yl group. The invention also relates to a process for preparing the products of formula (I) and to drugs containing said products.

Antibiotic derivatives, derived from cephalosporins with thiazolyl

The invention relates to derivatives of the family of cephalosporins, to a process for preparation thereof and to the therapeutic application thereof. The compounds of the invention correspond to formula: ##STR1## in which: ##STR2## is an acid, an alkaline or alkaline-earth salt, an amine salt or an ester;

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Saint Gely du Fesc, France

Ali Salhi