University of Copenhagen

Var2 Pharmaceuticals Aps

Ali Salanti

Thor Grundtvig Theander

Christoph Mikkel Janitzek

Susan Thrane

Morten Agertoug Nielsen

Mads Daugaard

Madeleine Dahlback

Jan Tobias Gustafsson

Morten Nielsen

Thomas Mandel Clausen

Adam Frederik Sander Bertelsen

Mette Ørskov Agerbaek

Mette Ørskov

Adam Frederik Sander Pedersen

Mette ØRskov AGERBÆK

Madeleine DAHLBÄCK

The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments of VAR2CSA, nucleic acids encoding such fragments of VAR2CSA as well as methods for their production. The invention further relates to conjugates and fusion proteins of VAR2CSA polypeptides including the minimal binding fragments and their use, in particular in the treatment of conditions associated with expression of chondroitin sulfate A (CSA), such as an inappropriate expression of chondroitin sulfate A (CSA).

Targeting of chondroitin sulfate glycans

The invention relates to a virus-like particle (VLP) based vaccine. The virus-like particle constitutes a non-naturally occurring, ordered and repetitive antigen array display scaffold which can obtain a strong and long-lasting immune response in a subject. The VLP-based vaccine may be used for the prophylaxis and/or treatment of a disease including, but is not limited to, cancer, cardiovascular, infectious, chronic, neurological diseases/disorders, asthma, and/or immune-inflammatory diseases/disorders.

Virus-like particle with efficient epitope display

The invention relates to a virus like particle (VLP) based vaccine. The virus-like particle constitutes a non-naturally occurring, ordered and repetitive antigen array display scaffold which can obtain a strong and long-lasting immune response in a subject. The VLP based vaccine may be used for the prophylaxis and/or treatment of a disease including, but is not limited to, cancer, cardiovascular, infectious, asthma, and/or allergy diseases/disorders.

Virus like particle with efficient epitope display

Growing community of inventors

Farum, Denmark

Ali Salanti