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Nano Hesgarsazan Salamat Arya Ncubation Center for Medical Equipment and Devices

Ali Saeidi

Mohammad Abdolahad

Milad Gharooni

An electromechanical system for detecting cancerous state of a single cell. The electromechanical system includes an aspirating mechanism, an electrical measurement mechanism, and a processing mechanism. The aspirating mechanism is configured to extract a single cell from a suspension of a plurality of suspended biological cells, hold the extracted single cell, and apply a mechanical aspiration to the held single cell by applying a suction force to the held single cell. The electrical measurement mechanism is configured to apply a set of electrical signals to the single cell before and after applying the mechanical aspiration and measure two sets of electrical responses from the held single cell corresponding to the applied set of electrical signals before and after applying the mechanical aspiration The processing mechanism, including a data processor, configured to detect cancerous state of the single cell based on a difference between the two sets of electrical responses.

Electromechanical approach for cancer detection

An electrical probe is disclosed for measuring an electrical response from a biological cell. The electrical probe includes a tungsten microwire having a sharpened tip section, a catalyst layer formed on the sharpened tip section of the tungsten microwire, and an array of nanotube electrodes vertically aligned on the catalyst layer. The catalyst layer includes a catalyst bilayer including a nickel layer over a gold layer, and the nanotube electrodes include a plurality of silicon nanotubes (SiNTs).

A single-cell-based electromechanical method for cancerous state detection including the steps of preparing a suspension of individually suspended biological cells, extracting a single cell from the suspension, holding the extracted single cell from the suspension, measuring a first electrical response of the held single cell, step-wised mechanical aspirating the held single cell to form a mechanically deformed cell, and measuring an electrical response of the held single cell after each step of mechanical aspirating. The cancerous state of the single cell is determined based on the changes in the measured electrical responses.

Growing community of inventors

Tehran, Iran

Ali Saeidi