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Sabanci Universitesi Nanoteknoloji Arastirma Ve Uygulama Merkezi

Sabanci Üniversitesi Nanoteknoloji Arastirma Ve Uygulama Merkezi Sunum

Progin Bilisim Mühendislik Ve Danismanlik Hizmetleri Ltd. Sti.

Ali Kosar

Devrim Gozuacik

Yunus Akkoc

Havva Yagci Acar

Ahmad Reza Motezakker

Osman Yavuz Perk

Muhammed Kocak

Ozlem Unal

Abdolali Khalili Sadaghiani

Mustafa Pinar Mengüc

Merve Zuvin

Kürsat Sendur

Moein Talebian Gevari

Mükerrem Ilker Sevgen

Sarp AKGÖNÜL

Devrim GÖZÜACIK

Mustafa Pinar MENGÜC

Morteza Ghorbani

Ibrahim Kursat Sendur

Mustafa Pinar Menguc

Ismail Cem Atalay

ÖZlem Kutlu

Sibel Cetinel

The present invention relates to oligonucleotide carriers for oligonucleotide delivery to a subject to provide gene therapy. More particularly, the present invention relates to therapeutic nanoparticles for microRNA (miRNA) delivery to a subject. More particularly, the present invention relates to therapeutic nanoparticles wherein miRNA is bindable to biocompatible nanoparticles using natural gene carrier Argonaute (AGO) protein or a variant thereof. Optionally, therapeutic nanoparticles of the present invention additionally contain targeting moieties for targeting therapeutic nanoparticles to cancer cells and/or chemotherapeutic agents. Optionally, biocompatible nanoparticles are trackable nanoparticles, such as superparamagnetic iron oxide nanoparticles (SPION), to provide multifunctional theranostics.

Therapeutic nanoparticles containing argonaute for microRNA delivery and compositions and methods using same

A device including a liquid's flow path having an upstream side and a downstream side, a plurality of flow restrictive elements providing material communication between the upstream side to the downstream side, a thermoelectric generator or a thermophotovoltaic cell in thermal connection with a portion of the device located at the downstream side with respect to the plurality of flow restrictive elements. The portion is provided with roughness elements for, in use, contacting a fluid flowing through the device and facilitating collapse of cavitation bubbles.

Energy harvesting device

A heat exchanger having a heat transfer surface provided with hyperthermophilic bacteria. The hyperthermophilic bacteria can be from the genera. The hyperthermophilic bacteria can further be from the genus, and the hyperthermophilic bacteria can further be from the species. The heat exchanger can be adapted to pool-boiling heat transfer.

Heat exchanger with enhanced heat transfer surfaces

A flow system for avoiding particle agglomeration in nanofluids, including a flow restrictive element, wherein the flow restrictive element in use provides sudden expansion to the fluid such that cavitation takes place the fluid upon exiting the flow restrictive element. The flow system includes the flow restrictive element having a hydraulic diameter within a range between 0.5 &#x3bc;m and 250 &#x3bc;m, a vicinity of the flow restrictive element is provided with a heater, adapted to heat the nanofluid in the vicinity of the flow restrictive element.

Flow system for avoiding particle agglomeration

A pharmaceutical drug delivery system having a base () comprising at least two inlets (), an outlet () and a passive mixing chamber () having micro pin fins () with heights in the range of 10 to 100&#x3bc;&#x3b9;&#x3c4;&#x3b9; characterized in that the base () is selectively coated with nanostructures which are made of a material different than the material of said base, such that the base () comprises a plurality of regions Rto Reach having a different nanostructure coating intensity, and such that a surface tension gradient is established among regions Rto Rfor promoting fluid flow towards the outlet (). The present invention further proposes a method for obtaining a pharmaceutical drug delivery system.

Pharmaceutical drug delivery system

An apparatus for using hydrodynamic cavitation in medical treatment such as destroying kidney stones or killing infected cancer cells. This apparatus comprises a tank used as a container for a fluid, a compressor connected to the tank to maintain the input pressure of the fluid, a tubing wherein the fluid flows, a probe in which the cavitation occurs, a valve positioned inside the tubing, allowing the fluid to flow into the probe, a filter positioned inside the tubing, preventing the predetermined size particles flowing into the probe, a fitting connecting the probe to the tubing, a flowmeter measuring the volume flow rate of the fluid through the probe, an image capturing unit capturing the sequential images of bubbles growing and bubbles collapsing after the bubbles exit from the probe, a positioning assembly which adjusts the distance between the probe and the target surface, and a control and data acquisition unit.

Apparatus for using hydrodynamic cavitation in medical treatment

Growing community of inventors

Istanbul, Turkey

Ali Kosar