St. Jude Medical Puerto Rico LLC

Access Closure, Inc.

Catharos Medical Systems, Inc.

Flea Street Translational, LLC

St. Jude Medical, Cardiology Division, Inc.

Ali Hassan

Peter J Fitzgerald

Brian Courtney

Jason M Halac

Troy White

Bernhard Kaeferlein

James A McCrea

Zihan Lin

Jose L Garcia

Andy H Uchida

Kevin To

Richard Cartledge

Zachary J Tegels

Yi Yang

Lester John Lloyd

Catherine A Pipenhagen

Ronald Ray Hundertmark

Martha Escobar

Leonard Y Lee

Wesley Chung Joe

Nicolas A F Chronos

Richard Domingo Yazbeck

Brian K Courtney

Michael Orth

Mark Yang

Binh Luong

Troy T White

Richard D Yazbeck

Wesley C Joe

A method of reducing the risk of clinical sequelae to catheter induced vascular injuries may include introducing a guide wire into a vascular sheath residing in a blood vessel, proximally retracting the vascular sheath while leaving the wire in place, and observing indicia of the presence or absence of a vascular injury caused to the blood vessel by the vascular sheath or a procedural catheter previously advanced through the vascular sheath. If indicia of a vascular injury are observed, the method may further involve proximally retracting the guide wire to position the inflatable balloon adjacent the injury and inflating the balloon to reduce blood flow past the injury, while leaving the guide wire in place to provide subsequent access to the injury. The inflatable balloon can be inflated and deflated through a valve positioned at the proximal end of the guide wire.

Method and devices for flow occlusion during device exchanges

A suture locking device includes a carrier member, a locking assembly, a suture path, and an actuator assembly. The locking assembly includes a first locking member having an outer surface portion, and a second locking member having an inner surface portion. The suture path is receptive of a suture and defined at least partially through the first locking member, between the outer and inner surface portions, and at least partially through the carrier member. The actuator assembly is operable to move the first and second locking members together to lock the suture relative to the lock assembly.

Suture locking device and methods

A suture locking device includes a suture locking assembly, a suture cutting member, and an actuator assembly. The actuator assembly includes a first actuator operable longitudinally to lock the suture with the suture locking assembly, and a second actuator operable laterally to concurrently cut the suture with the suture cutting member and disconnect the suture locking assembly from the suture locking device.

Methods and devices for maintaining vascular access and/or minimizing bleeding during percutaneous interventions. The method can include advancing an access wire through a previously placed access catheter in a contralateral femoral artery to position an inflatable balloon on the access wire in a vascular access sheath located in an ipsilateral femoral artery, without using any additional guidewires to advance the access wire. After withdrawing the vascular access sheath at least partway out of the ipsilateral femoral artery to expose the vascular injury, the balloon can be inflated to occlude the ipsilateral femoral artery or an ipsilateral iliofemoral artery at or near the vascular injury.

Methods, systems and devices for effectively and safely accessing and verifying a target site within a vessel or body cavity undergoing a catheter-based procedure or treatment. The present invention further includes the accurate delivery an instrument, an implantable device and/or materials to the target site. The present invention is particularly useful for transvenously assessing the suitability of a target site within the coronary vasculature for placement of a pacing electrode and transvenously placing the pacing electrode at the target site.

Sensor-assisted catheter-based procedures

A vascular closure system includes a body portion, an anchor, a suture carrying portion, and a plurality of needles. The body portion has a distal end surface. The anchor is positionable through a vessel puncture in a vessel wall of a vessel. The anchor defines a vessel contact surface, wherein withdrawal of the anchor captures a portion of the vessel wall between the vessel contact surface and the distal end surface. The suture carrying portion is positionable through the vessel puncture and carries at least one suture member. The plurality of needles extend through the portion of the vessel wall adjacent to the vessel puncture and are configured to connect to the at least one suture member. Withdrawal of the plurality of needles through the portion of the vessel wall positions the at least one suture member through the portion of the vessel wall.

Large bore closure device and methods

Methods and devices for modulating heart valve function are provided. In the subject methods, a heart valve is first in structurally modified. Blood flow through the structurally modified heart valve is then monitored, and the heart is paced in response to the monitored blood flow. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods find use in a variety of applications.

Methods and devices for modulation of heart valve function

A method for facilitating treatment of catheter induced vascular injuries may first involve introducing a guide wire into a vascular sheath residing in a blood vessel, where the guide wire has a distal end and an inflatable balloon at least 15 cm proximal of the distal end. The method may further involve proximally retracting the vascular sheath while leaving the wire in place and observing indicia of the presence or absence of a vascular injury caused to the blood vessel by the vascular sheath or a procedural catheter previously advanced through the vascular sheath. If indicia of a vascular injury are observed, the method may involve positioning the inflatable balloon at or near the vascular injury and inflating the balloon to reduce blood flow past the vascular injury, while leaving the guide wire in place to provide subsequent access to the injury.

Methods and devices for selectively removing an agent from a physiological site, e.g., a physiological efferent fluid collection site, are provided. Aspects of the invention include fluid removal (e.g., aspiration) devices having a fluid removal element and a flow modulator positioned at a distal end of the fluid removal element. The flow modulator is configured to converge intersecting fluid flow paths into the fluid removal element. Also provided are systems and kits for performing the subject methods. The subject invention finds use in a variety of different applications, including the selective removal of both therapeutic and diagnostic agents from a variety of different physiological sites.

Methods and devices for removal of a medical agent from a physiological efferent fluid collection site

Methods, systems and devices for establishing communication between organs and/or tissue lumens. The devices include catheters having magnetized distal ends which are configured to magnetically couple to each other such that a coaxial alignment is established between two or more catheters. The systems include two or more the subject catheters. The methods include use of the catheters and magnetically coupling them to establish a continuous passageway between them.

Methods, systems and devices for establising communication between hollow organs and tissue lumens

Methods and devices for selectively removing an agent from a physiological efferent fluid collection site are provided. A feature of the invention is that a non-occlusive aspiration device is employed to selectively remove the target agent from the site only when the target agent is present in the site. Also provided are systems and kits for performing the subject methods. The subject invention finds use in a variety of different applications, including the selective removal of both therapeutic and diagnostic agents from a variety of different physiological sites.

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Mountain View, CA, United States of America

Ali Hassan