Sirona Medical Technologies, Inc.

Cambridge Heart, Inc.

Spacelabs Healthcare

Vigilant Networks LLC

Ali Haghighi-Mood

Richard J Cohen

Neil Judell

Srivathsan Krishnamachari

Various catheters are provided herein for recording, mapping, and/or ablating target tissue to reduce or eliminate unwanted electrical impulses. In one embodiment, a catheter can have a handle, an elongate body, and an end effector. The end effector has expanded and contracted configurations and can rotate about the elongate body. A plurality of electrodes can also be disposed on the end effector for recording, mapping, and/or ablating target tissue surrounding the catheter. The handle can guide the end effector through transitioning between the configurations and rotating about the elongate body.

Multi-modal catheter for improved electrical mapping and ablation

Improved mapping and ablation procedures and corresponding devices are provided. A variety of methods and apparatuses can be used for the treatment of cardiac arrhythmias by identifying the location of an arrhythmia source and ablating that source. The methods and apparatuses can provide an improved means of electrical mapping of the heart to identify the location of the arrhythmia source and advancing an ablation electrode to that location so that it may be ablated.

Cardiac electrical mapping and ablation

Various catheters with expandable and contractible fluid pathways extending therethrough, and methods of use, are provided herein. In an exemplary embodiment, a catheter is provided with an elongate body having an electrode at the distal end thereof. One or more expandable members or wings can extend between the electrode and the distal end of the elongate body. The catheter can also include an actuator extending therethrough and coupled to the electrode such that movement of the actuator is effective to advance and retract the electrode, thereby moving the one or more expandable members between a collapsed configuration and an expanded configuration. The catheter can also include a fluid sealed lumen formed therein and configured to receive fluid and to deliver fluid to one or more pathways formed in the electrode. The actuator can extend through the fluid sealed lumen, however it can be fluidly separated from the lumen. The fluid sealed lumen can be configured to expand and collapse with movement of the electrode, while allowing movement of the actuator therethrough.

Catheter and method for improved irrigation

First cardiac signal data generated from measured heart beats of a subject is received. Characteristics of alternans occurring in the received first cardiac signal data are determined. Second cardiac signal data generated from measured heart beats of the subject after a change relating to an administration of a pharmacological agent is received. Characteristics of alternans occurring in the received second cardiac signal data are determined. The characteristics of alternans occurring in the received first cardiac signal data are compared with the characteristics of alternans occurring in the received second cardiac signal data.

Alternans and pharmacological agents

A method for identifying infants at risk for SIDS includes applying electrodes to an infant, receiving electrical signals from the electrodes, analyzing the received electrical signals to measure alternans of a heart of the infant, and identifying whether the infant is at risk for SIDS. A system for identifying infants at risk for SIDS includes an input unit configured to receive electrical signals from electrodes applied to an infant, a processor connected to the input unit and configured to process the received electrical signals to measure alternans of a heart of the infant, and a comparator configured to compare the measured alternans with alternans in a population of infants.

Identifying infants at risk for sudden infant death syndrome

Identifying infants at risk for SIDS includes applying electrodes to an infant, receiving electrical signals from the electrodes, analyzing the received electrical signals to measure alternans of a heart of the infant, and identifying whether the infant is at risk for SIDS. A system for identifying infants at risk for SIDS includes an input unit configured to receive electrical signals from electrodes applied to an infant, a processor connected to the input unit and configured to process the received electrical signals to measure alternans of a heart of the infant, and a comparator configured to compare the measured alternans with alternans in a population of infants.

A signal-based cable attenuation measurement device, system and methodology provides measurement of attenuation characteristics of a cable over a wide frequency spectrum. Located at a single location on a cable, a measurement device injects a signal on to the cable under measurement and receives the reflected signal, recording physical characteristics of the cable in response to the signal. A model, calibrated to estimate the effects of the cable with known impedances, evaluates the waveform generated from the cable's response to the signal and computes attenuation of the cable as a function of frequency. In some circumstances, when low signal-to-noise effects result, normally at high frequencies in long cables, the attenuation of the cable is further fitted to the model to correct the errors that occur as a result of the low signal-to-noise effects.

Single ended attenuation measurement

Alternans is measured in a physiological signal, such as an electrocardiogram, by processing the physiological signal to create a processed signal having an asymmetric spectrum, and processing the processed signal to measure alternans in the physiologic signal. The physiological signal may be processed to produce an analytical signal by converting the signal to the frequency domain, removing components corresponding to negative frequencies, and converting back to the time domain.

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Andover, MA, United States of America

Ali Haghighi-Mood