Gilead Sciences, Inc.

Mologen Ag

Alfredo Zurlo

Matthias Schroff

Manuel Schmidt

Kerstin Kapp

Ole Schmeltz Sogaard

Martin Tolstrup

Rasmus Offersen

The invention relates to a non-coding sequence of deoxyribonucleic acids comprising at least one sequence motif NNCGNN, wherein N is a nucleotide comprising A, C, T, or G, and C is deoxycytidine, G is deoxyguanosine, A is deoxyadenosine and T is deoxy-thymidine for the treatment of viral infections. In particular, the non-coding sequence of deoxyribonucleic acids is used in combination with antiretroviral therapy and/or histone de-acetylase inhibitors.

Methods of treating a retroviral infection

The invention relates to a combination and its use for the treatment of diseases. The instant disclosure provides a combination of a so-called T-cell regulator selected from the group comprising PD1, PD-L1, OX40, TIM-3, LAG3, CD137(4-1BB) and a non-coding immunomodulating DNA.

Combination comprising immunostimulatory oligonucleotides

The invention relates to a combination and its use for the treatment of diseases. The instant disclosure provides a combination of a so-called T-cell regulator selected from the group comprising PD1, PD-L1, OX40, TIM-3, LAGS, CD137(4-1BB) and a non-codiung immuno-modulating DNA.

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Berlin, Germany

Alfredo Zurlo