Universidad Del País Vasco

Alfredo Rodríguez-Antigüedad Zarranz

Carlos Matute Almau

Ainara Vallejo Illarramendi

Pablo Villoslada Díaz

Fernando Pérez Cerdá

Alberto Pérez Samartín

Estibaliz Etxebarria Galnares

María Domercq García

Ormaetxea Olatz Pampliega

The present invention refers to the use of glutamate transporters, glutamate and EGF to detect the presence of demyelinating diseases in a subject, to determine the status or severity of the same or to monitor the effects of a therapy administered to a subject who suffers from such diseases; to the use of the said markers for the searching, identification, development and evaluation of the efficacy of compounds for the treatment of such diseases, with a view to developing new drugs; to the use of compounds which promote the expression of the EAAT1 and EAAT2 transporters, as well as EGF for the treatment of demyelinating diseases. In a preferred embodiment, the methods and compounds of the invention are applicable to MS.

Method for the diagnosis and prognosis of demyelinating diseases

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Leioa-Vizcaya, Spain

Alfredo Rodríguez-Antigüedad Zarranz