University of Washington

Leland Stanford Junior University

Alfredo Quijano Rubio

David Baker

Marc J Lajoie

Daniel Adriano Silva Manzano

Umut Ulge

Scott Boyken

Robert A Langan

Walter Novak

Kenan Christopher Garcia

Shawn Yu

Jamie Spangler

Carl Walkey

Brian Weitzner

Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive ('off') state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain, components of such protein switches, and their use.

De novo design of protein switches

Conditionally active receptor agonists that, when activated, bind to IL-2 receptor βheterodimer (IL-2Rβ), IL-4 receptor αheterodimer (IL-4Rα), or IL-13 receptor a subunit (IL˜13 Rα) are disclosed, as are components of the conditionally active receptor agonists and methods for using the conditionally active receptor agonists.

Split interleukin mimetics and their use

De novo designed polypeptides that bind to IL-2 receptor &#x3b2;&#x3b3;heterodimer (IL-2R&#x3b2;&#x3b3;), IL-4 receptor &#x3b1;&#x3b3;heterodimer (IL-4R&#x3b1;&#x3b3;), or IL-13 receptor &#x3b1; subunit (IL-13R&#x3b1;) are disclosed, as are methods for using and designing the polypeptides.

De novo design of potent and selective interleukin mimetics

Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive ('off') state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates ('on') the bioactive peptide or binding domain, components of such protein switches, and their use.

Growing community of inventors

Seattle, WA, United States of America

Alfredo Quijano Rubio