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Ims-International Medical Service S.r.l.

Development Biotechnological Processes S.n.c Di Pelliccia Maria Teresa

Teslab S.r.l.

Development Biotechnological Processes S.n.c.

Alfredo De Rosa

Antonio Graziano

Gianpaolo Papaccio

Gregorio Laino

Riccardo D'Aquino

Armando Rossi

Francesco Carinci

Pietro Affaitati

Methods for the isolation, expansion and storage of a population of stem cells belonging to human dental follicles, called FENC (Follicle-derived Embryonic Neural Crest stem cells,) including: a) Collection of the follicular sack in sterile conditions, digestion and primary culture growth and expansion; b) Optional amplification; c) FACsorting.

Collection and selection methods to isolate a stem cell population from human adult periodontal follicular tissues

In this invention is described a method that foresees the isolation of a new subpopulation of stem cells derived form dental pulp, whose differentiation is osteoblasts lead to the subsequent production and employment of a bone tissue, called LAB (Living Autologous Bone). Specifically, the invention describes: 1) the isolation of stem cells from the pulp of deciduous and permanent teeth and of dental germs, obtained from human subjects; 2) the growth of these cells in vitro, under specific conditions that allow the isolation of a cellular sub-population, which, after differentiation in osteoblasts, is able to produce in vitro an extracellular matrix, identical to that detectable in bone tissue; 3) the use of this selected and differentiated cell population in order to produce autologous bone tissue in vitro, containing vital osteoblasts; 4) the preservation of the LAB under conditions which guarantee cellular vitality; 5) the use of the LAB in donor patients to reconstruct bone tissue, as required in the daily practice in dentistry, maxillo-facial surgery and orthopedics.

Stem cells obtained from pulp of deciduous or permanent teeth and of dental germ, able to produce human bone tissue

Thrombin inhibitors, the preparation thereof and the use thereof for

Process for the preparation of iodinated biopolymers having disinfectant

Growing community of inventors

Naples, Italy

Alfredo De Rosa