Ire-celltarg S.a.

Improbio

Alfredo Cravador

Alex Bollen

Sophie Houard

Marie-Joelle De Vos-Pierreux

Albert Herzog

The subject of the present invention is a nucleic acid probe containing a nucleic acid sequence, wherein the said sequence is linked at its 5' end, via a divalent bifunctional chemical 'arm' L, to a 'labeling component' M, M being a synthetic or natural molecule which is directly or indirectly detectable in a non-isotopic manner, according to the formula I: ##STR1## in which J=H or OH

Nucleic acid probe containing a terminal carbamyl linking

The present invention relates to probes of nucleic acids useful for detecting indifferently the various types of human papilloma virus, particularly HPV1a, HPV5, HPV6b, HPV8, HPV11, HPV16, HPV18 and HPV33, especially a probe comprising a labelled sequence of nucleic acids, characterized in that it comprises the oligomer of twelve nucleotides X-A-A-A-A-C-G-A-A-A-G-X, with X=T or U, or its complement by interchanging A and X on the one hand, C and G on the other hand. The present invention also relates to specific probes of nucleic acids for the detection of human papilloma for each of the types HPV1a, HPV5, HPV8, HPV11, HPV16, HPV18 and HPV33, as well as specific probes of sub-groups of the virus HPV16, HPV18, HPV33 or HPV16 and HPV18 only or again HPV5 and HPV8 only.

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Rhode-St-Genese, Belgium

Alfredo Cravador