Hoffmann-La Roche Inc.

F. Hoffmann-La Roche Ag

Alfred Ross

Hans Senn

Nicole Wyttenbach

Frank Dieterle

Martin Kuentz

Goetz Schlotterbeck

Jochem Alsenz

G&ouml;tz Schlotterbeck

Wiebke Svea Saal

Götz Schlotterbeck

The present invention provides novel, solid or liquid pharmaceutical preparations comprising a basic or neutral, low molecular weight active pharmaceutical ingredient and the polymer Eudragit&#xae; EPO, optionally together with additional pharmaceutically acceptable excipients. The present preparations are for oral or topical administration.

Pharmaceutical compositions for basic or neutral, low molecular weight compounds

A method for processing a set of spectra, particularly NMR spectra, by selecting a principle spectral range, recording a plurality of principle spectra in the principal spectral range, obtaining a reference principal spectrum in the principal spectral range, carrying out, for each one of the principal spectra, a bin-wise division of the principal spectrum by the reference principal spectrum to obtain a corresponding set of spectral quotients; calculating, for at least one of the principal spectra, an associated set of statistical measures derived from the corresponding set of spectral quotients, and carrying out, for at least one of the sets of statistical measures, an outlier detection test.

Method for processing a set of spectra, particularly NMR spectra

A method for estimating the number of nuclei of a preselected isotope in a molecular species starts with an NMR spectrum of a sample containing said molecular species as a predominant substance, said NMR spectrum comprising a plurality of signal peaks corresponding to said nuclei. By applying inclusion and ordering criteria one obtains a set of ordered signal peaks, the integration of which leads to a set of ordered integrals. Nested outer and inner iteration cycles are carried out, wherein for each cycle a trial number of nuclei is assigned to one of said ordered integrals whilst the other ordered integrals are rescaled accordingly and rounded to the next integer value, so as to yield a candidate total number of nuclei. An estimated total number of nuclei is obtained by taking the lowest one from the plurality of candidate total numbers of nuclei that have the highest number of occurrences.

Method for estimating the number of nuclei of a preselected isotope in a molecular species from and NMR spectrum

For simultaneously determining the analytical NMR spectra of a number of samples placed suitably arranged in the measuring site of an NMR measuring apparatus, spatially and timely varying magnetic fields are used. The resulting signals are spatially resolved by a suited processing, for example Fourier transform. Surprisingly, from these signals, analytical NMRs of high resolution can be obtained for each sample. The method can be applied to two-dimensional arrangements of samples, for example a bundle of capillaries imitating a conventional NMR sample tube or a well plate, or three-dimensional arrangements, for example stacks of well plates. The method allows the determination of NMR spectra for analysis or for comparison with anterior spectra for long time behavior studies and quality assessment with only a fraction of time needed for measuring the samples individually.

Spectroscopic measurement method using NMR

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Lörrach, Germany

Alfred Ross