Boehringer Mannheim Gmbh

Alfred Rhomberg

Herbert Berger

Wolfgang Vomel

Winfriede Sauer

Kurt Stach

Kurt Stach, Deceased

By Werner Plattner, Administrator

By Werner Plattner, Executor

Werner Plattner, Administrator

Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an alkylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

Compositions using cycloalkano-quinolone derivatives and their method of

New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,

Cyclopenteno[1,2-h]quinol-4-one derivatives

Nitrogen containing derivatives of cyclopenteno-quinolone compounds and

New cyclopenteno-quinolone derivatives of the formula ##SPC1## Wherein

Cyclopenteno-3-carboxyl-4-quinolone derivatives and their bacteriostatic

Certain novel cyclopentenoquinolone derivatives of the formula: ##SPC1## Wherein

Cyclopentenoquinolone compounds for treating bacterial infections

Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##SPC1## Wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an akylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

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Mannheim-Neuostheim, Germany

Alfred Rhomberg