Asta Medica, Aktiengesellschaft

Intendis Gmbh

Alfred Olbrich

Bernhard Kutscher

Jurgen Engel

Roland Moller

Karl-Friedrich Landgraf

Klaus Huthmacher

Herbert Klenk

Horst Bethge

Thomas Beisswenger

Stephan Rautenberg

Frank Hubner

Wolfgang Schumacher

Ulf Niemeyer

Rainer Gewald

Matthias Rischer

Gerhard Sator

Peter Meisel

Wilfried Thiel

Bernd Kutscher

Peter Emig

Gerhard Nossner

Hans Stange

J&uuml;rgen Sch&auml;fer

Steffen Schweizer

Siegfried Pauluhn

Gerhard Nssner

The current invention describes novel chiral synthetic routes and intermediates for the manufacture of chiral anti-inflammatory agents of general formula VIII 

Process for the manufacture of non-steroidal anti-inflammatory agents and intermediates thereof

Modifications of 2-amino-4-(4-fluorobenzylamino)-1-ethoxycarbonylaminobenzene, and processes for their preparation

A process for the preparation of C.sub.14 -C.sub.18 -alkylphosphocholines by reacting an n-alkanol with a chain length of C.sub.14 -C.sub.18 with phosphorus oxychloride in an inert solvent or also without solvent in the presence or absence of a basic substance in a single vessel process and subsequent reaction of the reaction product in an inert solvent with a choline salt in the presence of a basic substance to form phosphoric acid diester chloride, subsequent hydrolysis and isolation of alkylphosphocholine as well as optionally purification using a mixed-bed ion exchanger or in successive steps with an acid ion exchanger and a basic ion exchanger.

Process for the preparation of alkylphosphocholines and the production

The invention relates to the production and purification of salts of 6,8-bis (amidiniumthio)octanoic acid, its enantiomers (+)-6,8-bis(amidiniumthio)octanoic acid and (-)-6,8-bis (amidiniumthio)octanoic acid and of the esters of these compounds as well as to their use to produce dihydrolipoic acid and .alpha.-lipoic acid.

Production and use of salts of 6,8-bis (amidiniumthio)-octanoic acid

A process for preparation of pure flupertine maleate and the pure A crystalline form of flupertine maleate by the use of water soluble alcohols during synthesis and/or purification.

Process for the preparation of pure flupirtine maleate and its A

The invention relates to novel modifications of the compound 2-amino-4-(4-fluorobenzylamino)-1-ethoxy-carbonylaminobenzene of the formula I ##STR1## processes for their preparation and their use in pharmaceutical compositions.

Modifications of

This disclosure describes two technical procedures for the high-yield synthesis of heterocyclic seven-membered ring-systems by Dieckmann-condensation avoiding usual dilution techniques and long reaction times. Thus, it significantly increases the overall yields of the pharmaceutically active ingredients azelastine and flezelastine, whose synthesis, starting from these seven-membered heterocyclic rings, is reported elsewhere. Yields range from 80-89%, avoiding waste and increasing economics of the synthesis.

Method for the preparation of hexahydroazepinones and hexahydroazepinoles

The invention relates to the production and purification of salts of 6,8-bis(amidiniumthio) octanoic acid, its enantiomers (+)-6,8-bis(amidiniumthio)octanoic acid and (-)-6,8-bis (amidiniumthio)octanoic acid and of the esters of these compounds as well as to their use to produce dihydrolipoic acid and .alpha.-lipoic acid.

Production and use of salts of 6, 8-bis (amidiniumthio) -octanoic acid

Growing community of inventors

Obertshausen, Germany

Alfred Olbrich