Bertek, Inc.

Mli Acquisition Corp. Ii

Alfred Kwiatek

Ludwig J Weimann

Wayne C Pollock

Sharad K Govil

John J Wick

Devices for the controlled release of an active agent to the skin or mucosa of a host are disclosed, which devices are laminates of a cellular foam layer having a first surface and a second surface, which foam layer has an active agent incorporated therein; a backing layer having an inner surface and an outer surface, wherein the inner surface is affixed to the second surface of the foam layer so that the active agent cannot permeate from the second surface of the foam layer through the outer surface of the backing layer; and means for affixing the laminate to the skin or mucosa of the host so that the active agent is capable of being continuously released from the first surface of the foam layer thereto. Methods for assembling the laminate devices are also disclosed, as are methods in which the foam layer is formed from a prepolymer solution on the backing layer. Methods are also disclosed for the polymerization of cellular urethane foams having active agents uniformly dispersed therethrough.

Foam laminate transdermal patch

Devices for applying film layers and/or active agent carriers to the skin are disclosed, including a liner layer having a release surface, a carrier layer for the film layer, a first adhesive between the carrier layer and the film layer, and a second adhesive between the liner layer and the opposite surface of the film layer and carrier layer. In this manner, the film layer is sandwiched between the liner layer and carrier layer, and the coefficients of adhesion of the two adhesives are selected so that upon separation of the liner layer and the carrier layer the film layer remains on the carrier layer, and upon application of the film layer to the skin, the film layer transfers from the carrier layer to the skin. The device preferably includes a hinge permanently connecting a peripheral edge of the carrier layer to the liner layer in order to facilitate this process, and in a preferred embodiment an active agent carrier is either substituted for or added to the film layer.

Hinged dermal applicator

A method of manufacturing adhesive-backed sheet components having release liners attached to and covering the adhesive backs thereof, and an article made by such method are disclosed. The method comprises the steps of providing an elongate, marginally punched, continuous sheel substrate having a series of consecutive panels that are separable from one another along transverse score lines positioned therebetween; applying a layer of release coating material to a corresponding predetermined minor portion of each of the panels; applying a layer of pressure sensitive adhesive to at least a portion of the layer of the release coating material within the minor portion of each of the panels; applying a sheet component atop the pressure sensitive adhesive within the minor portion of each of the panels to adhere the sheet component to the panel; providing score lines about the periphery of the minor portion of each of the panels so as to allow the sheet component, the pressure sensitive adhesive layer, the release coating layer, and the minor portion of the panel to be removed from the remainder of the panel as an integral laminate unit; and, removing the integral laminate unit from the remainder of each of the panels. The article of this invention comprises the aforesaid sheet substrate having panels thereon each of which is provided with an integral laminate unit thereon that is separable therefrom.

Growing community of inventors

Bal Harbour, FL, United States of America

Alfred Kwiatek