Astrazeneca Ab

Alfred Arthur Rabow

Robert Hugh Bradbury

Michael James Waring

James Francis McCabe

Zoe Ann Cotter

Arshed Mahmood

Steven Christopher Glossop

Heather Marie Redfearn

David Buttar

Christopher De Savi

Craig Samuel Donald

Gordon Stuart Currie

Richard Albert Norman

Nadim Akhtar

Helen Elizabeth Williams

Matthew Osborne

Neda Yavari

Neil James Hales

Gregory Richard Carr

Srinivasa Rao Korupoju

Harikrishna Tumma

James Francis Mccabe

The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R, Rand n have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents.

[1,2,4]triazolo[4,3-b]pyridazines for use in the treatment of proliferative diseases

[1,2,4]triazolo[4,3-B]pyridazines for use in the treatment of proliferative diseases

The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein Rto Rhave any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Chemical compounds

The invention concerns compounds of Formula (I) (Formula (I)) or pharmaceutically-acceptable salts thereof, wherein R, Rand n have any of the meanings defined herein before in the description; processes for their preparation, pharmaceutical compositions containing them and their use as anti-proliferative and/or cell-killing agents. 

The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein Rto Rhave any of the meanings defined hereinbefore in the description: processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

The invention concerns bicyclic compounds of Formula I wherein, R, R, L, L, J, Y, k, n, p and r are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of androgen-receptor associated conditions, particularly prostate cancer.

Chemical compounds&#x2014;643

The invention concerns bicyclic compounds of Formula I wherein the integers X, X, X, Ring A, R, Rand m are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of androgen-receptor associated conditions.

Bicyclic derivatives for use in the treatment of androgen receptor associated conditions-155

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Macclesfield, United Kingdom

Alfred Arthur Rabow