Dr. Madaus & Co.

Alfonso Carcasona-Beltran

Rolf Hermann Madaus

Klaus Gorler

Werner Stumpf

The invention provides a novel acidic alkali citrate having the formula K.sub.6 Na.sub.6 H.sub.3 (C.sub.6 0.sub.7 H.sub.5).sub.5 . 2-4 H.sub.2 O made by dissolving either (a) trisodium citrate.times.2 H.sub.2 O, tripotassium citrate.times.1 H.sub.2 O, and citric acid in a mole ratio of 2:2:1 in 3 to 5 times the quantity by weight of boiling demineralized water, based on the weight of the citric acid and maintaining the solution at a temperature not lower than 60.degree. C.; or (b) citric acid at 90.degree. C. while stirring in .01 to 1 times its weight of demineralized water and then adding sodium carbonate and potassium carbonate to give a mole ratio of 3:3:5 of sodium carbonate: potassium carbonate:citric acid, and quick drying the homogeneous solution obtained. Therapeutic agents for the treatment of urolithiasis and removal, or preventing recurrence, of urine stones comprising said acidic alkali citrate are provided.

Acidic alkali citrate and compositions for adjusting the ph of urine

The invention provides a novel acidic alkali citrate having the formula K.sub.6 Na.sub.6 H.sub.3 (C.sub.6 O.sub.7 H.sub.5).sub.5.2-4 H.sub.2 O made by dissolving either

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Barcelona, Spain

Alfonso Carcasona-Beltran