Janssen Pharmaceutica Nv

Alfons G De Knaep

Luc J Moens

Eduard J Vreysen

Marc Gaston Venet

Alex Herman Copmans

Albert Louis Willemsens

Anna Maria Vandendriessche

Walter Louis Verstappen

A process for preparing (+)-6-�(4-chlorophenyl)(1H- 1,2,4-triazol-1-yl)methyl!-1-methyl-1H-benzotriazole comprising the resolution of (.+-.)-6-!(4-chlorophenyl)-hydrazinomethyl)-1-methyl-1H-benzotriazole and converting the appropriate enantiomerically pure hydrazine intermediate into (+)-6-�(4-chlorophenyl)(H- 1,2,4-triazol-1-yl)methyl!-1-methyl-1H-benzotriazole.

Process for preparing enantiomerically pure 6-{4-chlorophenyl) (1

Process for preparing enantiomerically pure 6-[(4-chlorophenyl)

Process for preparing enantiomerically pure imidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-thiones of formula ##STR1## starting from 2,6-dihalo-3-nitrobenzyl derivatives (II) and suitably N-protected 1,2-diaminopropanes (III) ##STR2## Novel enantiomerically pure intermediates of formula (III) and (IV) prepared in the course of the present process.

Process for preparing enantiomerically pure

Process for preparing enantiomerically pure imidazo[4,5,1 -jk][1,4]benzodiazepin -2(1H)-thiones of formula ##STR1## starting from 2,6-dihalo-3-nitrobenzyl derivatives (II) and suitably N-protected 1,2-diaminopropanes (III) ##STR2## Novel enantiomerically pure intermediates of formula (III) and (IV) are prepared in the course of the present process.

Intermediates for preparing enantiomerically pure

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Turnhout, Belgium

Alfons G De Knaep