Bristol-Myers Squibb Compnay

Astra Lakemedel Aktiebolag

Pharmacia & Upjohn Aktiebolag

Alf G Nicklasson

Bengt Herslof

Rolf I Sjoovist

Kjell J Mattsson

The invention relates to a lipid particle forming matrix, characterized by, that from a defined system of at least two lipid components chosen from classes of different polarity, in which at least one of the lipid components is bilayer forming, discrete lipid particles are formed spontaneously when interacting with aqueous systems. Preferably at least one of the lipid components is amphiphatic and polar and one is nonpolar. These discrete particles are formed spontaneously from the matrix without any chemical or physical treatment or initiation. The invention also relates to a process for producing the matrix and use thereof.

Lipid particle forming matrix, preparation and use thereof

An improved method for administering buspirone comprises oral administration of controlled/extended release formulations of buspirone and salts thereof which require from about 6 to 24 hours for in vitro dissolution of at least 80% of the buspirone content. Administration of these formulations increases buspirone bioavailability in relation to its major metabolite. Improved efficacy, drug tolerability and patient convenience result from this improved method of administration.

Method for administration of buspirone

A dosage form for oral administration of a pharmaceutically active substance characterized in that it includes a encapsulated or embedded pharmaceutically active substance in a pharmaceutically acceptable non-aqueous liquid.

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Sodertalje, Sweden

Alf G Nicklasson