Opko Ireland Global Holdings, Limited

Pq Silicas UK Limited

Cytochroma Development Inc.

Alexis John Toft

Maurice Sydney Newton

Nigel Peter Rhodes

James David Morrison

Ruth Diane Pennel

Richard Jonathan Applewhite

Ruth Diane Pennell

Simon Richard Stebbing

Stephen George Ellison

There is provided use of a mixed metal compound in the manufacture of medicament for neutralizing or buffering stomach acid, wherein the mixed metal compound contains at least one trivalent metal selected from iron (III) and aluminum and at least one divalent metal selected from of magnesium, iron, zinc, calcium, lanthanum and cerium, wherein (A) the mixed metal compound is of formula (I): MMOA.zHO (I) where Mis the at least one bivalent metal; Mis the at least one trivalent metal; Aat least one n-valent anion; 2+a=2b+&#x3a3;cn and &#x3a3;cn&#x3c;0.9a, and z is 2 or less, and/or (B) the mixed metal compound is provided in the form of a granular material comprising (i) at least 50% by weight, based on the weight of the granular material, of the mixed metal compound (ii) from 3 to 12% by weight, based on the weight of the granular material, of non-chemically bound water, and (iii) no greater than 47% by weight based on the weight of the granular material of excipient.

Mixed metal compounds used as antacids

The present invention relates to mixed metal compounds having pharmaceutical activity, especially as phosphate binders. It also extends to methods of manufacture of those compounds, as well as to pharmaceutical compositions containing such compounds. It further relates to their pharmaceutical use. In particular, the present invention relates to use of compounds of Formula (I): MMwherein M&#x2033; is at least one bivalent metal (i.e. with two positive charges); M1 is at least one trivalent metal (i.e. with three positive charges); and 1&#x3e;a&#x3e;0.4.

Mixed metal compounds for treatment of hyperphosphataemia

There is provided a granular material comprising (i) at least 50% by weight based on the weight of the granular material of solid water-insoluble mixed metal compound capable of binding phosphate of formula (I): M.M(OH)A.zHO (I) where Mis at least one of magnesium, calcium, lanthanum and cerium; Mis at least iron(III); Ais at least one n-valent anion; x=&#x3a3;ny, 0&#x3c;x&#x2266;0.67, 0&#x3c;y&#x2266;1, and 0&#x2266;z&#x3c;10; (ii) from 3 to 12% by weight based on the weight of the granular material of non-chemically bound water, and (iii) no greater than 47% by weight based on the weight of the granular material of excipient.

Water-insoluble, iron-containing mixed metal, granular material

The present invention provides a composition comprising (i) a mixed metal compound containing at least one trivalent metal selected from iron (lll) and aluminum and at least one divalent metal selected from of magnesium, iron, zinc, calcium, lanthanum and cerium, (ii) xanthan gum (iii) at least one of (a) polyvinyl pyrrolidone (b) locust bean gum (c) methyl cellulose wherein the composition has been irradiated with ionizing radiation in an amount of at least 4 kGy.

Composition comprising mixed metal compounds and xanthan gum

There is provided a granular material comprising (i) at least 50% by weight based on the weight of the granular material of solid water-insoluble mixed metal compound capable of binding phosphate of formula (I): MM(OH)A.ZHO (I) where Mis at least one of magnesium, calcium, lanthanum and cerium; Mis at least iron(III); Ais at least one n-valent anion; x=&#x3a3;ny; 0&#x3c;x&#x2266;0.67, 0&#x3c;y&#x2266;1, and 0&#x2266;z&#x3c;10; (ii) from 3 to 12% by weight based on the weight of the granular material of non-chemically bound water, and (iii) no greater than 47% by weight based on the weight of the granular material of excipient.

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Warrington, United Kingdom

Alexis John Toft