Roussel Uclaf

Aventis Pharma S.a.

Fab Pharma S.a.s.

Hoechst Marion Roussel

Laboratoire Biodim

Fab Pharma

Oroxcell

Denis, Alexis

Alexis Denis

Constantin Agouridas

Jean-Francois Chantot

Odile Le Martret

Claude Fromentin

Vincent Gerusz

Yannick Benedetti

Mayalen Oxoby

Sonia Escaich

Yannick Bonvin

Alain Bonnefoy

Francois Bretin

Jean-Francedillaois Chantot

Solange Gouin d'Ambrieres

Christophe Dini

Bertrand Heckmann

Fabien Faivre

Solange G D'Ambrieres

Giuseppe Gigliotti

Jean Pachot

Jean-Marie Pejac

Odile L Martret

François Moreau

Jean-Michel Auger

The invention relates to novel heterocyclic acrylamide compounds (I), to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments and pharmaceutical compositions containing the compounds.

Heterocyclic acrylamides and their use as pharmaceuticals

The invention relates to hydroxyphenyl derivatives of formula (I); and uses thereof as anti-bacterial and/or anti-parasitic agents.

Hydroxyphenyl derivatives and biological applications thereof

The invention relates to a novel hydroxyphenyl compound, to the preparation of the compound and intermediates used therein, to the use of the compound as an antibacterial medicament and pharmaceutical compositions containing the compound.

Antibacterial hydroxyphenyl compound

The invention relates to novel heterocyclic acrylamide compounds (I), to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments and pharmaceutical compositions containing the compounds. 

The invention relates to hydroxyphenyl derivatives of formula (I); and uses thereof as anti-bacterial and/or anti-parasitic agents. 

The invention relates to Imidazolo-heteroaryl derivatives of formula (I). The compounds inhibit the activity of the Dlta enzyme of Gram-positive bacteria and are useful to treat Gram-positive bacterial infections. Furthermore the application discloses method for assessing the Dlta inhibitory activity of tested molecules and a method for measuring the efficacy of molecules in inhibiting bacteria proliferation in vitro. 

Imidazolo-heteroaryl derivatives with antibacterial properties

2-amino-2-phenyl-alkanol ester derivatives of general formula (I) in which: Ris H, straight or branched 1 to 4C alkyl, straight or branched 2 to 4C alkyl substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino, alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, Ris a &#x2014;CO&#x2014;R radical in which R is H, alkyl, aryl, heterocyclyl, benzyl or heterocyclylmethyl, or Ris a &#x2014;CO&#x2014;Y&#x2014;Rradical for which Y is &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;NH&#x2014;, -Nalk- for which alk is straight or branched (1 to 4C) alkyl, and Ris alkyl, aryl, aralkyl or heterocyclylalkyl, capable of being substituted by one or more halogen atoms or OH radicals, straight or branched (1 to 4C) alkyl, alkoxy, alkylthio, acylaminoalkylthio, alkoxycarbonyl or acylamino (1 to 4C) straight or branched, or oxo, or capable of being substituted by RCOO&#x2014; in which Ris alkyl optionally substituted by benzyloxycarbonylamino, acylamino or by an amino acid residue, or represents an heterocyclyl radical, or Ris alkyl (2 to 4C) substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino optionally forming, with the nitrogen atom to which they are attached, a 5- or 6-member heterocycle optionally having another heteroatom (O or N), or substituted by alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, it being understood that said straight or branched substituted alkyl radical comprises at least 2C between &#x3e;N&#x2014;Rand the substituent; and Ris alkyl (1 to 4C) straight or branched unless specifically mentioned, alkyl or acyl are straight or branched (1 to 7C), in their R or S forms or their mixtures, as well as their pharmaceutically acceptable salts when these exist. 

2-amino-2-phenyl-alkanol derivatives, their preparation and pharmaceutical compositions containing them

Novel compounds of the formulawherein the substituents are defined as in the application having antibiotic properties.

2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and their antibiotic use

A subject of the invention is a process for the preparation of the compounds of formula (I): Wherein the substituents are defined as in the application. The compounds of this invention exhibit antibiotic properties.

2-halogenated derivatives of 5-O-desosaminyl-erythronolide A, their preparation process and their antibiotic use

The invention concerns compounds of formula (I) wherein: X represents a (NH)a, CH or SO radical or an oxygen atom; a represents 0 or 1; Y represents a (CH )m-(CH&boxH;CH)n-(CH )o radical with m&plus;n&plus;o&lE;8, n&equals;0 or 1; Ar represents an aryl or heteroaryl radical, optionally substituted; W represents a hydrogen atom or a halogen atom; Z represents a hydrogen atom or an acid residue, and their addition salts with acids. The compounds of formula (I) have antibiotic properties

6-deoxy erythromycin derivatives, method for preparing same and use as medicines

Derivatives of erythromycin, their preparation process and their use as medicaments

Derivatives . . . use as medicaments

Erythromycin derivatives, a process for their preparation and their use as medicaments

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Paris, France

Alexis Denis