Combinatorx, Incorporated

Massachusetts Institute of Technology

University of Iowa Research Foundation

The Broad Institute, Inc.

Editas Medicine, Inc.

Zalicus, Inc.

Alexis Borisy

Curtis Keith

Michael Andrew Foley

Palaniyandi Manivasakam

Edward Roydon Jost-Price

Nicole Hurst

Grant R Zimmermann

Feng Zhang

Beverly L Davidson

Jordi Mata-Fink

Brent R Stockwell

Edgardo Rodriguez

Deborah Palestrant

Jason Fong

Robyn Sackeyfio

Michael S Slavonic

Brendan Smith

Benjamin A Auspitz

Grant Zimmerman

Michael A Foley

Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.

CRISPR-related methods and compositions with governing gRNAS

CRISPR-related methods and compositions with governing gRNAs

The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.

Methods and reagents for the treatment of immunoinflammatory disorders

The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid.

Combinations for the treatment of immunoinflammatory disorders

The invention features methods and compositions for the treatment of immunonflammatory disorders.

Combinations for the treatment of inflammatory disorders

The invention features a method for treating a patient having an immunoinflammatory disorder, by administering to the patient (i) a tetra-substituted pyrimidopyrimidine, and (ii) a corticosteroid simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit immunoinflammation.

The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.

Combinations of drugs for the treatment of neoplastic disorders

The invention features a pharmaceutical composition that includes amoxapine and a corticosteroid.

The invention features a method for treating a patient having an inflammatory disorder, by administering to the patient (i) a tricyclic antidepressant (e.g., amoxapine); and (ii) a corticosteroid (e.g., prednisolone) simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit inflammation.

The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) a benzimidazole or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within 14 days of each other in amounts sufficient to inhibit the growth of the neoplasm.

Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders

The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) chlorpromazine or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within 14 days of each other in amounts sufficient to inhibit the growth of the neoplasm.

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Alexis Borisy