Bionano Genomics, Inc.

Alexey Y Sharonov

Parikshit A Deshpande

Michael David Austin

Han Cao

Michael Kochersperger

Mark Kunkel

Kandaswamy Vijayan

Michael Boyce-Jacino

Ming H Xiao

Valeriy Bogdanov

Michael Austin

Ming Xiao

Michael D Austin

Provided are integrated analysis devices having features of macroscale and nanoscale dimensions, and devices that have reduced background signals and that reduce quenching of fluorophores disposed within the devices. Related methods of manufacturing these devices and of using these devices are also provided.

Integrated analysis devices and related fabrication methods and analysis techniques

Integrated analysis device analysis techniques

Provided are devices and methods for polymer analysis, in which labeled polymers are translocated along nanochannels that have illuminated detection regions within. As a labeled polymer translocates along the nanochannel and the labels pass over the illuminated detection regions, the labels become detectable (e.g., where different labels fluoresce in response to different wavelengths present at different illumination regions), and the user generates a spatial map of the location of the various labels along the length of the polymer. The location of the labels is then correlated to one or more structural characteristics of the polymer.

Nanochannel arrays and near-field illumination devices for polymer analysis and related methods

Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g., determining structural variations and copy number variations between individuals.

Methods and devices for single-molecule whole genome analysis

Growing community of inventors

San Diego, CA, United States of America

Alexey Y Sharonov