Siemens Aktiengesellschaft

Siemens Healthcare Gmbh

Alexey Tsymbal

Dorin Comaniciu

Michael Kelm

Shaohua Kevin Zhou

Bogdan Georgescu

Yefeng Zheng

Razvan Ioan Ionasec

Michael Sühling

Dime Vitanovski

Maria Jimena Costa

Andreas Greiser

Edgar Mueller

Anna Jerebko

Gareth Funka-Lea

Ingmar Voigt

Michael Wels

Fernando Vega-Higuera

Dominik Bernhardt

Martin Sedlmair

Olivier Pauly

Martin Huber

Sonja Zillner

Sushil Mittal

Alexander Schwing

Dimitrij Zharkov

Huber Martin

A method is disclosed for the automatic determination of the bone density and a method is disclosed for the automatic detection and characterization of spinal column fractures. Both methods enable the fully automatic detection and assessment of damaged vertebrae and reliably enable an analysis of the state of the vertebrae with a high accuracy rate. A computed tomography system to carry out either of the methods is further disclosed.

Method for the fully automatic detection and assessment of damaged vertebrae

A method for generating a synthetic two-dimensional mammogram with enhanced contrast for structures of interest includes acquiring a three-dimensional digital breast tomosynthesis volume having a plurality of voxels. A three-dimensional relevance map that encodes for the voxels the relevance of the underlying structure for a diagnosis is generated. A synthetic two-dimensional mammogram is calculated based on the three-dimensional digital breast tomosynthesis volume and the three-dimensional relevance map.

Generating a synthetic two-dimensional mammogram

An embodiment of the method is disclosed for non-invasive lesion candidate detection in a patient's body includes generating a number of first medical images of the patient's body. The method further includes identifying lesion-like geometrical regions inside the first medical images of the patient's body by applying image processing methods, whereby the identification is at least partly controlled by a number of patient-specific context features which are not directly extractable from the first medical images. In addition, the method includes selecting a number of the identified lesion-like geometrical regions as lesion candidates.

Method and system for lesion candidate detection

A system and method for regression-based segmentation of the mitral valve in 2D+t cardiac magnetic resonance (CMR) slices is disclosed. The 2D+t CMR slices are acquired according to a mitral valve-specific acquisition protocol introduced herein. A set of mitral valve landmarks is detected in each 2D CMR slice and mitral valve contours are estimated in each 2D CMR slice based on the detected landmarks. A full mitral valve model is reconstructed from the mitral valve contours estimated in the 2D CMR slices using a trained regression model. Each 2D CMR slice may be a cine image acquired over a full cardiac cycle. In this case, the segmentation method reconstructs a patient-specific 4D dynamic mitral valve model from the 2D+t CMR image data.

Method and system for regression-based 4D mitral valve segmentation from 2D+t magnetic resonance imaging slices

A method and system for providing medical decision support based on virtual organ models and learning based discriminative distance functions is disclosed. A patient-specific virtual organ model is generated from medical image data of a patient. One or more similar organ models to the patient-specific organ model are retrieved from a plurality of previously stored virtual organ models using a learned discriminative distance function. The patient-specific valve model can be classified into a first class or a second class based on the previously stored organ models determined to be similar to the patient-specific organ model.

Method and system for medical decision support using organ models and learning based discriminative distance functions

A method of performing image retrieval includes training a random forest RF classifier based on low-level features of training images and a high-level feature, using similarity values generated by the RF classifier to determine a subset of the training images that are most similar to one another, and classifying input images for the high-level feature using the RF classifier and the determined subset of images.

Image processing using random forest classifiers

A method and system for providing detecting and classifying coronary stenoses in 3D CT image data is disclosed. Centerlines of coronary vessels are extracted from the CT image data. Non-vessel regions are detected and removed from the coronary vessel centerlines. The cross-section area of the lumen is estimated based on the coronary vessel centerlines using a trained regression function. Stenosis candidates are detected in the coronary vessels based on the estimated lumen cross-section area, and the significant stenosis candidates are automatically classified as calcified, non-calcified, or mixed.

Method and system for automatic detection and classification of coronary stenoses in cardiac CT volumes

A medical ontology may be used for computer assisted clinical decision support. Multi-level and/or semantically grouped medical ontology is incorporated into a machine learning algorithm. The resulting machine-learnt algorithm outputs information to assist in clinical decisions. For example, a patient record is input to the algorithm. Based on the incorporated medical ontology, similarities are aggregated in different groups. An aggregate similarity of at least one group is a function of an aggregate similarity of at least another group. One or more similar patients and/or outcomes are identified based on similarity. Probability based outputs may be provided.

Medical ontologies for machine learning and decision support

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Erlangen, Germany

Alexey Tsymbal