University of Pittsburgh

Alexey Solovyev

David Okonkwo

Yoram Vodovotz

Qi Mi

Maxim Mikheev

Gregory M Constantine

Jorg Gerlach

A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.

Growing community of inventors

Pittsburgh, PA, United States of America

Alexey Solovyev