Sutro Biopharma, Inc.

Alexei M Voloshin

Gang Yin

Christopher James Murray

James Rozzelle

James F Zawada

Daniel Gold

Nathan Uter

James Edward Rozzelle

This invention provides for a novel means of incorporating non-native amino acids into preselected positions of a protein using a cell-free synthesis system. The methods involve the use of non-orthogonal, native isoaccepting sense tRNAs that are encoded by the genetic code. Such methods allow for numerous non-native amino acids to be incorporated through the use of sense codons without having to rely upon orthogonal tRNA-synthetase pairs.

Mono charging system for selectively introducing non-native amino acids into proteins using an in vitro protein synthesis system

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South San Francisco, CA, United States of America

Alexei M Voloshin