University of Arkansas

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Alexandru S Biris

Zeid Nima

Alexandru Radu Biris

Yang Xu

Mariya Khodakovskaya

Jon Gardner Wilkes

Dan Alexander Buzatu

Jerry Darsey

Dwight Wayne Miller

Meena Mahmood

Dan Lupu

Andrew G Kumpuris

Anna Radominska-Pandya

Steven Trigwell

Karrer M Alghazali

Enkeleda Dervishi

Lloyd A Bumm

Abhijit Biswas

Zhongrui Li

Ganesh K Kannarpady

Ilker S Bayer

Daoyuan Wang

Hussain Al-Rizzo

Carlos I Calle

Peder Jensen

Daniel Rucker

Taha Elwi

Ali T Abdulhussein

Walter Hatfield

Daniel Casciano

Mohamed Hassen Lahiani

Anwer Dheyaa Mahdi Mhannawee

Zeid A Nima

A nanoagent for detections and treatments of multiple targets of interest includes multiple types of nanocomposites, each type of nanocomposites comprising at least one nanostructure, each nanostructure having a core and a shell surrounding the core; a respective reporter assembled on the shell of each nanostructure; and a layer of a respective treating agent and a respective targeting agent conjugated to the respective reporter. In use, each type of nanocomposite targets to a respective target of interest according to the respective targeting agent and releases the respective treating agent and the nanostructure therein for therapeutic treatment of the respective target of interest, and the respective target of interest transmits at least one signature responsive to the respective reporter for detection of the respective target of interest.

Nanocomposites and nanoagents for detection and treatment of a target of interest and methods of making and using same

The disclosure relates to an expandable scaffold and a method for fabricating the scaffold. The expandable scaffold includes a three-dimensional porous structure comprising a composite material composed by a first material and a second material. The 3D porous structure has a tunable expansion capacity. When applied in a liquid, the 3D porous structure may uptake the liquid and expand from an original volume to an expansion volume up to 1000 times of the original volume. The 3D porous structure may be formed by a plurality of layers of the composite material, and architecture and shape of the layers of the composite material are arranged in accordance with a shape and a size of the expansion volume. Applications of the scaffold may include a bone or soft tissue regeneration system or a bleed stopping device.

Expandable bone and tissue regeneration system, and applications of same

A method of making a nanocomposite includes forming at least one gold nanorod; coating a silver layer on an outer surface of the gold nanorod; assembling a Raman reporter molecule layer on the coated silver layer; coating a pegylated layer on the assembled Raman reporter molecule layer; and conjugating the coated pegylated layer with an active layer, the active layer comprising at least one of a targeting molecule configured to bind to the target of interest and a functional molecule configured to interact with the target of interest.

Nanocomposites and methods of making same

A method for forming a biocompatible structure includes the steps of forming a layered structure having alternatively disposed first layers and second layers, where the first layers includes at least one polymer and first particles, and the second layers includes second particles; and treating the layered structure with a washing solvent to form the biocompatible structure, where the first particles are solvable in the washing solvent.

Biocompatible structure for tissue regeneration and methods of making and using same

A method of making at least one nanocomposite for surface enhanced Raman spectroscopy (SERS) detection of a target of interest includes forming at least one gold nanorod; coating a silver layer on an outer surface of the gold nanorod; assembling a Raman reporter molecule layer on the coated silver layer, wherein the Raman reporter molecule layer comprises Raman reporter molecules that are detectable by the SERS; coating a thiolated polyethylene glycol (PEG) layer on the assembled Raman reporter molecule layer; and conjugating the coated thiolated PEG layer with molecules of an antibody to make the at least one nanocomposite.

Nanocomposites, methods of making same, and applications of same for multicolor surface enhanced Raman spectroscopy (SERS) detections

A medium for fast, selective oil-water separation and/or oil absorption includes steel wool modified with a polymer a polymer or a polymer mixture. The polymer or the polymer mixture is adapted such that the medium is a superwetting material that is superhydrophobic and superoleophilic under water. The polymer or the polymer mixture includes polydimethylsiloxane, polytetrafluoroethylene, polyvinylpyrrolidone, or a combination thereof. The solution immersion method used to synthesize the medium requires only a single, simple step and affordable materials and, as a result, is easy to scale up.

Magnetic, superhydrophobic and superoleophilic medium, synthesizing methods and applications of same

A nanocomposite for detection and treatment of a target of interest including tumor cells or pathogens includes at least one nanostructure, each nanostructure having a core and a shell surrounding the core; a reporter assembled on the shell of each nanostructure; and a layer of a treating agent and a targeting agent conjugated to the reporter. In use, the nanocomposite targets to the target of interest according to the targeting agent and releases the treating agent and the nanostructure therein for therapeutic treatment of the target of interest, and the target of interest transmits at least one signature responsive to the reporter for detection of the target of interest.

Nanocomposites, methods of making same, and applications of same for multicolor surface enhanced raman spectroscopy (SERS) detections

A method of increasing the probability and rate of seed germination, increasing vegetative biomass, and increasing water uptake in seeds, in which a seed is introduced to an effective concentration of carbon nanomaterial. The effective concentration of carbon nanomaterial is 10-200 &#x3bc;g/mL.

Method of using carbon nanotubes to affect seed germination and plant growth

A two dimensional (2D) active plasmonic scaffold includes a polymer film and one or more nanoparticle layers disposed on the polymer film. The nanoparticles has functional groups attached thereon. A three dimensional (3D) structure fabricated using the 2D scaffold.

Graft scaffold with plasmonic activity, and methods of making and using same

A biocompatible structure includes one or more base structures for regeneration of different tissues. Each base structure includes alternately stacked polymer layers and spacer layers. The polymer layer includes a polymer and tissue forming nanoparticles. The polymer includes polyurethane. The tissue forming nanoparticles includes hydroxypatites (HAP) nanoparticles, polymeric nanoparticles, or nanofibers. The spacer layer includes bone particles, polymeric nanoparticles, or nanofibers. The weight percentage of tissue forming nanoparticles to the polymer in the polymer layer in one base structure is different from that in the other base structures. A method of producing the biocompatible structure includes forming multiple base structures stacked together, coating the stacked multiple base structures, and plasma treating the coated structure.

Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same

One aspect of the present invention relates to a multicomponent and biocompatible nanocomposite material, including a graphene structure formed with a plurality of graphene layers; and gold/hydroxyapatite (Au/HA) nanoparticles distributed within the graphene structure; where the nanocomposite material is formed by heating an Au/HA catalyst thin film with a carbon source gas to perform radio frequency chemical vapor deposition (RF-CVD).

Multicomponent and biocompatible nanocomposite materials, methods of synthesizing same and applications of same

A method of treating bone deficiencies includes applying a biocompatible structure to an implant surgical site. The biocompatible structure includes multiple polymer layers stacked to have a predetermined shape, multiple bone particle layers disposed between each of two neighboring polymer layers of the multiple polymer layers, and a coating surrounding the polymer layers and bone particle layers. Each of the polymer layers is formed with a polymer and first tissue forming nanoparticles. The predetermined shape is configured to conform to the implant surgical site.

Growing community of inventors

Little Rock, AR, United States of America

Alexandru S Biris