Sensors for Medicine & Science, Inc.

Alexandre V Nikolaitchik

George Y Daniloff

Aristotle G Kalivretenos

David Parker

Arthur E Colvin

Aristole G Kalivretenos

Edwin E Ullman

Compositions and methods for determining the presence or concentration of glucose in a sample which may also contain an alpha-hydroxy acid or a beta-diketone. The method uses a compound having at least two recognition elements for glucose, oriented such that the interaction between the compound and glucose is more stable than the interaction between the compound and the alpha-hydroxy acid or beta-diketone, such that the presence of the alpha-hydroxy acid or the beta-diketone does not substantially interfere with said determination.

Detection of glucose in solutions also containing an alpha-hydroxy acid or a beta-diketone

Compositions and methods for determining the presence or concentration of an analyte in a sample by exposing the sample to an indicator molecule comprising a fluorescent lanthanide metal chelate complex. The presence or concentration of the analyte in the sample is determined by observing and/or measuring the change in intensity of fluorescence emitted by the lanthanide metal chelate complex upon binding of the analyte to one or more recognition elements in the complex. The fluorescent indicator molecules can be used in various types of fluorescent sensing devices and are useful in various fields, including energy, medicine and agriculture.

Detection of analytes by fluorescent lanthanide metal chelate complexes containing substituted ligands

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Frederick, MD, United States of America

Alexandre V Nikolaitchik