Nestec S.a.

Societe Des Produits Nestle S.a.

Alexandre Panchaud

Annick Mercenier

Sophie Helene Nutten

Carine Blanchard

Michael Affolter

Isabelle Bureau-Franz

Francoise Maynard

Françoise Maynard

Sophie Nutten

The invention relates to newly identified peptides of that are capable of inducing tolerance to cow's milk, especially to &#x3b2;-lactoglobulin. The peptides may be administered to mammals, especially to young infants who are at risk of allergy to cow's milk proteins, to induce oral tolerance to cow's milk; they may also be administered to children or adults who are allergic to cow's milk to allow 'desensitization' towards the allergenic milk proteins, especially &#x3b2;-lactoglobulin, to occur. The peptides may also be used to induce tolerance to goat's and buffalo's milk proteins, especially &#x3b2;-lactoglobulin. The peptides are capable of modulating the mammalian immune response to allergens.

Newly identified peptides for use in the induction of oral tolerance in young mammals

A composition including protein hydrolysates derived from milk is obtained by the treatment of enzymes derived from microorganisms. A trypsin-like enzyme and a chemotrypsin-like enzyme are used. The composition is in particular intended for inducing tolerance in infants with the effect of modulating the potential occurrence of allergies later in life. The composition can also be used in sick adult patients. Preferably the composition is an infant formula, infant follow-up formula, growing-up milk or baby food or an enteral complete nutritional composition.

Milk-based protein hydrolysates and infant formulae and nutritional compositions made thereof

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Lausanne, Switzerland

Alexandre Panchaud