Biomerieux, Inc.

Hospices Civils De Lyon

Centre Hospitalier Universitaire De Nantes

Hospices Civils De Lyon (hcl)

Biomerieux Sa

Bioaster

Alexandre Pachot

Guillaume Monneret

Alain Lepape

François Mallet

Fabienne Venet

Bruno Mougin

Tanguy Fortin

Julien Textoris

Karim Asehnoune

Marilyne Dupin

Sylvie Pons

Estelle Peronnet

Marie-Angelique Cazalis

Antoine Roquilly

Bernard Allaouchiche

Aurélie Gouel-Cheron

Audrey Larue-Triolet

Marie-Angélique Cazalis

Sylvie Tissot

Virginie Moucadel

Thomas Rimmelé

Laurence Vachot

Disclosed herein is a method for the diagnosis/prognosis of a septic syndrome based on a biological sample from a patient. The method may include extracting biological material the biological sample, contacting the biological material with at least one specific reagent that is selected from specific reagents for the target genes having a nucleic acid sequence of any one of SEQ ID NOs: 1 to 28, and determining the expression of at least one of the target genes.

Method for diagnosis and/or prognosis of a septic syndrome

A method for determining a patient's susceptibility of contracting a nosocomial infection that includes obtaining a biological sample from the patient and extracting biological material from the biological sample; preparing a specific reagent of an expression product of at least one target gene selected from S100A9 and S100A8 target genes; and determining the expression of at least one of the target genes S100A9 and S100A8, where overexpression relative to a specified threshold value indicates susceptibility of contracting a nosocomial infection.

Methods for determining a patient's susceptibility of contracting a nosocomial infection and for establishing a prognosis of the progression of septic syndrome

The present invention relates to a method for the diagnosis/prognosis of a septic syndrome based on a biological sample from a patient, characterized in that it comprises the following steps:

A method for predicting the risk of developing a disseminated infection in a patient admitted to intensive care having no clinical symptoms of such infection includes: determining a first dose of gelsolin G1 in a biological sample from the patient originating from a first sample taken at time T1, carried out between the day of intensive care admission and 48 hours afterward; determining a second dose of gelsolin G2 in a biological sample from the patient originating from a second sample taken at time T2, carried out two to three days after the first sampling; calculating the variation between the dose of gelsolin G2 and the dose of gelsolin G1, giving a &#x394; value; and comparing the &#x394; value to a threshold value S determined beforehand from two patient populations admitted to intensive care, one not having developed a disseminated infection and the other having developed such an infection.

Prediction of the risk of developing a disseminated infection for patients admitted to an intensive care unit

A method and a kit for establishing an in vitro prognosis on a patient exhibiting SIRS, the method comprising: (i) measuring the level of expression of the CX3CR1 gene in vitro from the biological material of a patient sample by bringing into contact said sample with a specific reagent of the CX3CR1 gene; and (ii) comparing the expression level of the CX3CR1 gene of the patient to a predetermined expression threshold; wherein (iii) if the expression level of the CX3CR1 gene of the patient is less than the predetermined expression threshold, the survival prognosis of the patient is poor, and if the expression level of the CX3CR1 gene of the patient is greater than the predetermined expression threshold, the survival prognosis of the patient is good.

Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS

The present invention relates to a method for diagnosing and/or predicting a septic syndrome, wherein: The present invention also relates to a kit for diagnosing and/or predicting a septic syndrome.

Method for diagnosing and/or predicting of a septic syndrome

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Sulignat, France

Alexandre Pachot