Auburn University

Edward Via College of Osteopathic Medicine—auburn

Alexandre M Samoylov

Vitaly J Vodyanoy

Oleg Pustovyy

Tatiana I Samoylova

Ludmila Globa

Edward E Morrison

Nilmini Viswaprakash

Anna M Cochran

Lewis G Scharpf

Bryan A Chin

Kenny V Brock

Valery A Petrenko

Nancy R Cox

James Barbaree

Suram T Pathirana

Iryna Sorokulova

James W Gillespie

Viswaprakash Nanduri

W Charles Neely

Valery A Pentrenko

Disclosed are recombinant bacteriophage constructs and related exogenous peptide sequences for generating immune responses against CD47. The disclosed recombinant phage constructs bind to antibodies against CD47 and can be administered to an animal to generate an immune response against CD47, including generating anti-CD47 antibodies. The disclosed recombinant phage may comprise an amino acid sequence of CD47, epitopic fragments, variants, or functional mimics thereof. Also disclosed are methods for making and selecting such recombinant phage constructs and compositions that comprise such constructs (e.g., compositions for inducing an immune response against CD47 including pharmaceutical or veterinary compositions used as vaccines). Also disclosed are recombinant polynucleotides comprising genomic nucleic acid of the recombinant phage constructs disclosed herein.

Phage-peptide constructs for stimulating an immune response against CD47

Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals, which include landscape bacteriophage. The disclosed compositions may include immunogenic compositions or vaccines.

Phage constructs, sequences and antigenic compositions for immunocontraception of animals

A composition, system and method for modifying an olfactory response to an odorant is disclosed. In some embodiments, the composition includes crystalline metal nanoparticles dispersed in an aqueous medium. The composition is applied to olfactory tissues using a suitable applicator or dispenser. The metal nanoparticles are believed to interact with a G-protein coupled to receptor located in the cilia to moderate (enhance or reduce) sensitivity or ability to smell particular odorants. In accordance with an embodiment of the invention, the composition includes one or more odorants.

Compositions for and methods of controlling olfactory responses to odorants

Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed 'proteons' are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation of proteon nucleation centers (PNCs) upon which the proteons of the present in blood and other biological materials form. In another aspect of the invention, the PNCs are comprised of metallic nanoclusters.

Methods for detecting misfolded proteins in biological samples

Processes for isolating proteon nucleation centers (PNCs) from a biological sample obtained from an animal

Methods and compositions for identifying and characterizing one or more ligands of a peptide are provided. In particular, the invention provides a phage ligand sensor device (PLSD) comprising a sensor coupled to a binding element of interest. Binding elements of interest comprise phage displaying at least one foreign peptide. The PLSD and assays find particular use in identifying and characterizing ligand-peptide interactions.

Phage ligand sensor devices and uses thereof

Methods and compositions for evaluating the affinity of one or more ligands of interest are provided. In particular, a ligand sensor device (LSD) comprising a sensor coupled to a peptide of interest is provided. Assays using the LSD allow detection of ligand-peptide interactions directly in tissue samples and thus provide an in vitro assay to characterize peptide ligands. The LSD and assays find particular use in characterizing cell-specific peptides isolated from in vivo screening in animals to determine their suitability for use in human therapy.

Ligand sensor devices and uses thereof

Method of isolation and self-assembly of small protein particles from blood and other biological materials

Growing community of inventors

Auburn, AL, United States of America

Alexandre M Samoylov