Genentech, Inc.

Other

Xenon Pharmaceuticals Inc.

Alexandre Lemire

Avi J Ashkenazi

Fei Wang

Ramsay Beveridge

Jean-Philippe Leclerc

Daniel P Sutherlin

Claudio F Sturino

Kwong Wah Lai

Steven McKerrall

Liang Zhao

Jacob Bradley Schwarz

Wendy Lee

Georgette M Castanedo

Birong Zhang

Nicole Blaquiere

Paul Gibbons

Michael Scott Wilson

Cuong Q Ly

Marie-Gabrielle Braun

Joachim Rudolph

Philippe Bergeron

Zhiguo Liu

Andre B Charette

Wenfeng Liu

Leo Fu

Alexandre Cote

Nicole Alice Blaquiere

Described herein are phenoxy-pyridyl-pyrimidine compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I structure or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Phenoxy-pyridyl-pyrimidine compounds and methods of use

The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain. The following compound is illustrative: 

Therapeutic compounds and methods of use thereof

The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y&#x2014;Y, R, R, R, R, and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

There are provided methods for preparing diorganozinc compounds of formula RZn. For example, such a method can method comprise reacting together a compound of formula ZnXwith at least one compound chosen from compounds of formulas RMT, RM, and RM. R, X, M, M, and T can be various different chemical entities. Compounds of formula RZnR, in which Rand Rare the same or different, can also prepared in a similar manner.

Methods for preparing dioranozinc compounds

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Montreal, Canada

Alexandre Lemire