Assistance Publique-hopitaux De Paris

Centre National De La Recherche Scientifique

Université Paris Diderot-paris 7

Occlugel

Biosepra S.a.

Université Paris-sud 11

L'assistance Publique-hopitaux De Paris Etablissement Public De Sante

Alexandre Laurent

Michel Wassef

Laurence Moine

Denis Labarre

Laurent Bedouet

Egisto Boschetti

Pierre Girot

Ludovic O Drouet

Stéphanie Louguet

Michel Brouard

Stephanie Louguet

Valentin Verret

Emeline Servais

Van Nga Nguyen

Minh Tam Baylatry

Anouk Bisdorf-Bresson

Jean-Pierre Saint-Maurice

Khelil Slimani

The present invention relates to a macromolecule-loaded bioresorbable crosslinked polymer wherein the polymer is obtainable from the polymerization of: (i) at least one monomer of formula (I) (CH&#x2550;CR)CO&#x2014;K wherein: &#x2014;K represents O&#x2014;Z or NH&#x2014;Z, Z representing (CRR)&#x2014;CH, (CH&#x2014;CH&#x2014;O)&#x2014;H, (CH&#x2014;CH&#x2014;O)&#x2014;CH, (CH)&#x2014;NRRwith m representing an integer from 1 to 30; &#x2014;R, R, R, Rand Rindependently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker, and wherein the macromolecule is chosen in the group consisting of proteins and nucleic acids.

Implantable bio-resorbable polymer charged with fragile macromolecules

The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH&#x2550;CR)CO&#x2014;K (I) wherein: K represents 0-Z or NH&#x2014;Z, Z representing (CRR)&#x2014;CH, (CH&#x2014;CH&#x2014;O)&#x2014;H, (CH&#x2014;CH&#x2014;O)&#x2014;CH, (CH)&#x2014;NRRwith m representing an integer from 1 to 30; R, R, R, Rand Rindependently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker.

Implantable bio-resorbable polymer

The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH&#x2550;CR)CO&#x2014;K (1) wherein: &#x2014;K represents O&#x2014;Z or N H&#x2014;Z, Z representing (CRR)m-CH, (CH&#x2014;CH&#x2014;O)m-H, (CH&#x2014;CH&#x2014;O)m-CH, (CH)m-NRRwith m representing an integer from 1 to 30; &#x2014;R, R, R, Rand Rindependently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: &#x2014; R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; &#x2014;i and j represent independently an integer chosen between 0 and 2; &#x2014;X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C&#x2014;C and (iii) at least one bio-resorbable block copolymer cross-linker. 

Implantable swellable bio-resorbable polymer

An injectable biomaterial containing a non-aqueous solvent suitable for injection to a human being and nanoparticles made of a polymer that is insoluble in water and insoluble in the non-aqueous solvent, in which the nanoparticles are loaded with a drug or a biological agent. The injectable biomaterial is suitable for occluding normal or malformative blood vessels or non-circulating cavities, or for necrosing tumors.

Injectable biomaterial

A charged biomaterial including at least one first hydrophilic polymer, and superparamagnetic iron oxide particles complexed with a second hydrophilic polymer substantially identical to or different from the first hydrophilic polymer, wherein the superparamagnetic iron oxide particles complexed with the second hydrophilic polymer are distributed substantially homogeneously and substantially without aggregates in the first hydrophilic polymer. A process for preparing a charged biomaterial including forming an aqueous solution of hydrophilic monomers and superparamagnetic iron oxide particles complexed with a hydrophilic polymer including monomers substantially identical to or different from the hydrophilic monomers, polymerizing the solution and forming a polymer hydrogel in which are distributed substantially homogeneously and substantially without aggregates the superparamagnetic iron oxide particles complexed with the hydrophilic polymer.

Hydrophilic polymer biomaterial having a specific magnetic resonance imaging signal and process for the preparation of said biomaterial

The present invention concerns the use of microspheres for therapeutic embolization consisting of a hydrophilic acrylic copolymer coated with a cell adhesion promoter.

Microspheres useful for therapeutic vascular occlusions and injectable

Growing community of inventors

Courbevoie, France

Alexandre Laurent