Other

Aventis Pharma S.a.

Sanofi

Institut National De La Recherche Agronomique

Forest Laboratories Holdings Limited

Synchrotron Soleil

Institut National De La Recherche Agronomique (inra)

Pfizer Ireland Pharmaceuticals

Alexandre Giuliani

Mahendra G Dedhiya

Alain Bonnet

Pascal Billot

Alain Priour

Sisir Bhattacharya

Valérie Ravaux

Peter Spargo

Véronique Ducandas

Hagit Elmaleh

Patricia Rortais

Lionel Zaske

Marielle Dufraigne

Fabrice Mangin

Marc-Antoine Perrin

Matthieu Refregiers

Aleksandar Milosavljevic

Laurent Nahon

Didier Brige

Slavka Kascakova

Veronique Ducandas

Valerie Ravaux

The invention relates to anhydrides, solvates and ethanol hetero-solvates and hydrates of dimethoxy docetaxel or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate of 4-acetoxy-2&#x3b1;-benzoyloxy-5&#x3b2;,20-epoxy-1-hydroxy-7&#x3b2;, 10&#x3b2;-dimethoxy-9-oxo-tax-11-ene-13&#x3b1;-yle, and to the preparation thereof.

Crystalline forms of dimethoxy docetaxel and methods for preparing the same

The invention relates to a tandem mass spectrometer comprising an ionization source that can produce ions; a mass analyzer comprising an ion trap arranged in such a way as to receive ions from the ion source and a detector that can detect ions leaving the ion trap according to the mass to charge (m/z) ratio thereof; ion activation means for activating ions that can fragment at least some of the ions trapped in the ion trap; and coupling means arranged between the ion trap and said ion activation means. According to the invention, the ion activation means consists of a glow discharge lamp that can generate a light beam oriented towards the ion trap, said light beam being electromagnetic radiation in the vacuum ultraviolet wavelength range with photon energies of between 8 eV and 41 eV in such a way as to fragment at least some of the ions trapped in the ion trap.

Tandem mass spectrometer and tandem mass spectrometry method

Disclosed is a system and method of mass spectrometry, including: a. ionizing an analyte to form a precursor ion (A) having a mass-to-charge ratio (m/z), in which m represents the mass and z the electric charge number; b. activating the precursor ion (A) by interaction with a beam of neutral species, ions, electrons or photons, having an energy chosen on the basis of the physicochemical properties of the precursor ion, the activation being suitable for producing a product ion (B, C) having the same mass m as the precursor ion (A) and an electric charge number z' such that z&#x2032; is a non-zero integer different from z; c. separating the product ion (B, C, E, F) having a predefined mass-to-charge ratio (m/z&#x2032;); d. detecting the product ion (B, C) having the predefined mass-to-charge ratio (m/z&#x2032;).

System and method of detection and quantification by mass spectrometry and by activating ionised molecular species

The present invention relates to novel crystalline forms of sodium salt of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide (e.g., NXL-104) thereof. The present invention relates to compositions comprising a crystalline form of sodium salt of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide (e.g., NXL-104) alone or in combination with an antibacterial agent (e.g., ceftaroline fosamil). Processes for the preparation of the crystalline forms and methods of treating bacterial infections by administering the crystalline forms alone or in combination with an antibacterial agent (e.g., ceftaroline fosamil) are also described.

Crystalline forms of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt

The present invention relates to a process of preparation of Crystal Forms of 4-(cyclopropylmethoxy)-N-(3,5-dichloro-1-oxidopyridin-4-yl)-5-methoxypyridine-2-carboxamide of formula (I), said Crystal Forms which are designated as Crystal Forms A to I A and their use as a medicament.

Method of preparation of crystal forms of 4-(cyclopropylmethoxy)-n-(3,5-dichloro-1-oxidopyridyn-4-yl)-5-methoxypyridine-2-carboxamide and crystal forms thereof

Crystalline forms of trans-7-oxo-6-(sulphooxy)-1,6-Diazabicyclo[3,2,1]octane-2-carboxamide sodium salt

The invention relates to anhydrides, solvates and ethanol hetero-solvates and hydrates of dimethoxy docetaxel or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate of 4-acetoxy-2&#x3b1;-benzoyloxy-5&#x3b2;,20-epoxy-1-hydroxy-7&#x3b2;,10&#x3b2;-dimethoxy-9-oxo-tax-11-ene-13&#x3b1;-yle, and to the preparation thereof.

The invention relates to anhydrides, solvates and ethanol hetero-solvates and hydrates of dimethoxy docetaxel or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenyl-propionate of 4-acetoxy-2&#x3b1;-benzoyloxy-5&#x3b2;,20-epoxy-1-hydroxy-7&#x3b2;, 10&#x3b2;-dimethoxy-9-oxo-tax-11-ene-13&#x3b1;-yl, and to the preparation thereof.

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Paris, France

Alexandre Giuliani