Assistance Publique-hopitaux De Paris

Sorbonne Université

Carthera

Université Pierre Et Marie Curie (paris 6)

Edwards Lifesciences Corporation

Other

Assistance Publique-hopitaux De Paris Etablissement Public

Dixi Microtechniques Societe Par Actions Simplifiee

Institut National De La Sante Et De La Recherche Medicale

Université Pierre Et Marie Curie

Vermon S.a.

L'assistance Publique - Hopitaux De Paris

Itzcovitz, Julian

Carthera S.a.s.

Dixi Microtechniques S.a.s.

Alexandre Carpentier

Michael Canney

Alain F Carpentier

Jean-Yves Chapelon

Francois Lacoste

Cyril Lafon

Guillaume Bouchoux

Matthieu Cholvy

Alexandre Vignot

An Nguyen-Dinh

Than Nguyen

Hung Ly Lam

Crystal M Cunanan

Van Le Huynh

Julian Itzcovitz

Françoise Chavrier

Rémi Dufait

William Apoutou N'Djin

Christophe Notard

François Lacoste

Kévin Beccaria

Christophe Boillon

William Apoutou N'djin

Michael Sean Canney

Kevin Beccaria

An assembly for imaging and/or treating brain tissue, having at least one acoustic window which comprises a plate that is transparent to ultrasonic waves, and at least one positioning marker which facilitates positioning of a probe for generating ultrasonic waves so as to be aligned with said acoustic window.

Assembly for imaging and/or treating brain tissue

The present invention relates to a method for controlling a probe for the treatment of brain tissue using an assembly comprising the probe and an acoustic window (), the probe () including a plurality of transducers () for generating ultrasound waves, the method comprising: —a phase of detection: •of the probe transducers situated above the cranium () of the patient, and •of the probe transducers situated above the acoustic window (), so as to permit: •deactivation of the transducers situated above the cranium () of the patient, •activation of the transducers situated above the acoustic window ().

Control method for the treatment of brain tissue using an ultrasonic probe and an implanted acoustic window on the cranium

The present invention relates to a surgical kit for use in a craniectomy procedure, the surgical kit comprising: a medical device to be implanted in a cranial bone of a patient, the medical device () including several transducers for emitting ultrasound waves for treatment of brain tissue, a surgical accessory () intended to be positioned on the cranial bone of the patient, the surgical accessory () including a body whose outer perimeter defines the dimensions of an opening that is to be made in the cranial bone of the patient in order to receive the medical device, characterized in that the surgical accessory () comprises a plurality of holes () formed in the body, the position of each hole () on the body coinciding with the position of the axis of symmetry of a respective transducer, such that the accessory is able to be positioned optimally through the joint use of a neuronavigation system.

Surgical kit for use in a craniectomy procedure

An implantable ultrasound generating treating device () to induce spinal cord or spinal nerves treatment, suitable for implantation in the spinal canal and comprises an elongate support member () and an array of several treatment transducers () distributed along the elongate support member. The several treatment transducers () comprise radial transducers emitting an ultrasound treatment beam oriented radially, wherein the treatment transducers () have a resonant frequency comprised between 0.5 and 4 MHz. The device has articulating portions so that the implantable device can adapt its shape to a curved elongation path. Also disclosed is an apparatus including the implantable ultrasound generating treating device and methods comprising inserting the implantable ultrasound generating treating device () inside the spinal canal of the spine of the patient.

Implantable ultrasound generating treating device for spinal cord and/or spinal nerve treatment, apparatus comprising such device and method

An apparatus having an implantable ultrasound generating treating device to induce brain disorder treatment, suitable for implantation in or under the skull bone of a patient, includes several ultrasound generating transducers, which are connectable by a common electrical connection circuit to a generator, and wherein the ultrasound generating transducers each have one or several operating frequencies. The transducers include the group of transducers having several transducers driven by a same electrical drive signal, and connected to the generator system by a common electrical connection circuit, where the electric drive signal serves both as power signal and as a control signal for operating selectively, within said group, at least one or the other of a first transducer or sub-group of transducers, and of a second transducer or sub-group of transducers. The apparatus is also used to treat brain disorders.

Implantable ultrasound generating treating device for brain treatment, apparatus comprising such device and method implementing such device

An external ultrasound generating treating device () to induce spinal cord and/or spinal nerve treatment comprises at least two sub-arrays of ultrasound generating treatment transducers, a left sub-array (L) being located on a left lateral side and a right sub-array (R) being located on a right lateral side of the central longitudinal axis (Ai). The device comprises a support structure () having at least one module () comprising a left lateral section (L) and a right lateral section (R). The support structure () maintains, in use of the device, a constant distance and a constant relative angular orientation around the central longitudinal axis (Ai) between the first left and first right treatment transducers or set of treatment transducers (L,R). Also disclosed is an apparatus including the external ultrasound generating treating device () and methods of its use.

External ultrasound generating treating device for spinal cord and/or spinal nerve treatment, apparatus comprising such device and method

An interstitial ultrasound thermal ablation applicator for conformal treatment of an inhomogeneous tumor lesion includes: a body having a longitudinal axis; and a plurality of array transducers mounted on the body, arranged side by side and having azimuth directions parallel to the longitudinal axis of the body, and having outer faces disposed in a polygonal arrangement; the plurality of array transducers having predetermined elevation dimensions defined for directing emitted ultrasonic energy to obtain a conformal volume treatment of the tumor lesions. An electronic driving method for driving an applicator having multiple independent transducer elements arranged in rows and columns includes: controlling focal parameters of each row and column of transducer elements; and controlling a contribution of each row and column of transducer elements in a manner to provide a conformal ablated volume.

Interstitial ultrasonic disposable applicator and method for tissue thermal conformal volume ablation and monitoring the same

The present invention relates to a method for transiently disrupting a region of the blood-brain barrier (BBB) of a human using ultrasounds in the presence of an ultrasound contrast agent, and uses thereof. The method comprises the application of at least one ultrasound (US) beam with a pressure level higher than 1 MPa and a resonance frequency ranging from 0.5 to 1.5 MHz.

Method for transiently disrupting a region of the blood-brain barrier of a human

A system for treating at least one sensory capacity of a person with the help of a stimulation device comprises an electronic converter of a sensory signal into an electronic signal for controlling at least one transducer for emitting signals that are images of the sensory signal. The stimulation device for direct ultrasound stimulation of the sensory cortex of a brain comprises at least one support that is implantable in a skull and that includes at least one internal wall and at least one ultrasound transducer carried by the support. Means for emitting focused ultrasound waves through the internal wall of the support towards a determined zone of the sensory cortex of the patient's brain in order to generate modulation of the brain activity in the cortex are provided. The ultrasound transducer is driven by the electronic converter to emit focused ultrasound signals that are images of the sensory signal.

Device for treating the sensory capacity of a person and method of treatment with the help of such a device

The present invention relates to an apparatus for the treatment of a brain affection, which comprises at least one implantable generator () made of non-ferromagnetic material comprising a casing (), an ultrasound generating treating device () positioned into said casing to induce brain affection treatment by emission of ultrasound waves, and means for fastening the implantable casing into the skull. The apparatus further comprises a power controller (PwC) to supply electricity to the treating device of the implantable generator and to set and control its working parameters, and connecting means () to connect the power controller and the treating device of the implantable generator. A method for treating a brain affection with such an apparatus is also disclosed.

Apparatus for the treatment of brain affections and method implementing thereof

The percutaneous probe, made in MRI-compatible materials, comprises: a body percutaneously inserted into the tissue of a patient's body organ () having a region () to be analyzed, treated and monitored during a single medical procedure; at least one information collection sensing device (); treatment application transducers () 360&#xb0; disposed to emit focused or defocused therapeutic ultra-sound waves. The computerized system comprises a parametrizable command device () adapted to simulate then command a generation of the therapeutic ultra-sound waves, and to monitor the treatment by thermal MRI images.

Medical system comprising a percutaneous probe

An intracerebral electrode () which includes a narrow elongated body () for being implanted in a patient's brain. The body has contact pads () that are electrically connected to a measuring apparatus, and a mounting member () for attachment to the body to the patient's head. The electrode body has a closed distal end () and is hollow for receiving a treatment instrument (). The intracerebral electrode () comprises a closed inner fluid flow circuit () formed inside the body () of the electrode to an area adjacent the closed distal end (), and a connection mechanism () located outside the body which connects the closed inner fluid flow circuit to an outer fluid flow circuit so that fluid, flowing through the outer fluid flow circuit, flows into the electrode through the inner fluid flow circuit and controls the temperature of the electrode ().

Intracerebral electrode

An intracerebral probe () comprising a first part () with laser or cryogenic treatment means and further comprising a hollow second part () surrounding the first, the first part sliding inside the second part along its longitudinal axis (A); and a plurality of detectors () distributed along a portion of the second part () in such a manner as to be capable of identifying a brain dysfunction zone along the longitudinal axis (A) of the second part. Advantageously, the probe presents a lateral treatment window enabling the action of the treatment means to be directed. The invention also provides a kit and a treatment system including such a probe, and the use thereof of treating cell dysfunctions that give rise to neurological or psychiatric symptoms.

Intracerebral probe and device for the treatment of neurological or psychiatric dysfunctions

An expandable annuloplasty ring which may either expand spontaneously, in situ, as the patient grows or be expanded by surgical intervention by balloon dilatation. The distensible annuloplasty ring of the invention may be usable in pediatric patients whose growth, subsequent to surgical implantation of the ring, will necessitate subsequent enlargement of the ring to accommodate growth of the annulus. The ring may include a solid core of non-elastic material which plastically retains its shape upon natural expansion of the annulus, or after surgical expansion. A discontinuity may be positioned along the anterior side of the ring or around the posterior side.

Growing community of inventors

Paris, France

Alexandre Carpentier