Association for the Advancement of Tissue Engineering and Cell Based Technologies & Therapies (a4tec) - Associacão

Association for the Advancement of Tissue Engineer

Tintex - Textiles, S.a.

Hydrumedical, S.a.

Alexandre António Antunes Barros

Rui Luis Gonçalves Dos Reis

Ana Rita Cruz Duarte

Estêvão Augusto Rodrigues De Lima

Carlos André Ribeiro Oliveira

Jorge Manuel Nunes Correia Pinto

Ana Patrícia Da Rocha Cardoso

António José Monteiro Rodrigues

Maria José Machado

Carla Joana Dos Santos Marinho Da Silva

Luís Filipe Do Carmo Crispim Ribeiro

Rodrigo José Tarrio Agreiro Bezerra

Ivo Manuel De ASCENSÃO Aroso

João Carlos Fernandes Da Silva

Tiago José Quinteiros Lopes Henriques Da Silva

Rui Luis GONÇALVES Dos Reis

Rui Luís GONÇALVES Dos Reis

Helena Filipa Da Cunha Fernandes

Bruno Guilherme Gonçalves De Matos

Pedro Tiago Da Cruz Peixoto

Pedro Bragança

André Filipe Fernandes Da Silva Andrade Leite

Hugo Filipe Simões Costa

Sara Carvalheira Neves

Catarina Pires Sepúlveda

The present disclosure relates to biodegradable ureteral stents comprising an anti-cancer drug, and to a composition for use in medicine that may be used to ensure patency of a channel, namely a mammal ureter, for example, an obstructed ureter by a urinary stone, neoplasia or by a surgical procedure. The biodegradable ureteral stents (BUS) disclosed in the present disclosure unexpectedly allow a proper release of anti-cancer drugs, thus extending the duration of the treatment and increasing the efficacy of the treatment.

Biodegradable ureteral stents, methods and uses thereof

Stents and methods for producing stents are provided. The stent includes a polymeric substrate comprised of 10-50% (w/w) of alginate and 45-85% (w/w) of gelatine and further includes a polymeric biodegradable resin for coating said polymeric substrate. The stent can also include a contrast agent. The stent can further include a crosslinking agent. The method for producing the stent includes dissolving the alginate and gelatine in water and stirring to obtain a polymeric substrate. The method also includes adding a crosslinking agent to the substrate, injecting the substrate into a mold to obtain the stent, placing the stent in a first alcohol solution, and placing the stent in a crosslinking agent solution. The method further includes placing the stent in a second alcohol solution, and a series of interchanging drying and immersing steps.

Ureteral stent, methods and uses thereof

Growing community of inventors

Braga, Portugal

Alexandre António Antunes Barros