Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Commissariat a L'energie Atomique

Alexandra Savatier

Michel Leonetti

Jean-Claude Boulain

Adeline Gadzinski

Herve Volland

Patricia Lamourette

Anne Wijkhuisen

Céline Cousin

Culina Slobodan

Hervé Volland

The invention relates to a molecular complex for targeting the antigen towards cells comprising antigens, including at least one antigen associated with at least two ligands of surface molecules of cells comprising antigens, said complex including at least one first ligand of a sulphated sugar of the glycosaminoglycan family and a second ligand of a specific surface molecule of cells comprising antigens, and said first ligand being covalently bonded with said antigen and/or said second ligand.

Molecular complex for targeting antigens towards cells comprising antigens and uses thereof for vaccination

A method for the in vitro immunization of human B lymphocytes, comprising culturing a total mononuclear cell population of human peripheral blood in the presence of an antigenic composition comprising at least one antigen covalently bonded to both: (i) a Tat protein or a Tat fragment capable of oligomerization and (ii) a ligand of a surface molecule specific to the antigen presenting cells; a method for producing antigen-specific human antibodies derived from said in vitro immunization method.

Method for obtaining antigen-specific human antibodies by in vitro immunisation

Growing community of inventors

Etampes, France

Alexandra Savatier