Flagship Pioneering Innovations Vii, LLC

Alexandra Rachael Sneider

Geoffrey Von Maltzahn

Jacob Rosenblum Rubens

Molly Krisann Gibson

Benjamin Andrew Portney

Narahari Subbanna Pujar

Camilo Ayala Breton

The disclosure provides, for example, single stranded, covalently closed DNA that does not form a double stranded structure longer than 100 base pairs. The ssDNA may encode an effector sequence, for instance a therapeutic protein. The ssDNA may comprise a nuclear targeting sequence (NTS). In some embodiments, the ssDNA shows decreased activation of the innate immune system compared to an otherwise similar dsDNA.

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Cambridge, MA, United States of America

Alexandra Rachael Sneider