Health Innovation Ventures B.v.

Auckland Uniservices Limited

Victoria Link Limited

Convert Pharmaceuticals Sa

Alexandra Marie Mowday

Jeffrey Bruce Smaill

Adam Vorn Patterson

Amir Ashoorzadeh

David Francis Ackerley

Christopher Paul Guise

Janine Naomi Copp

Elsie May Williams

William Alexander Denny

William Robert Wilson

Ho Huat Lee

Jack Urquhart Flanagan

Guo-Liang Lu

Stephen Michael Frazer Jamieson

Robert Forbes Anderson

Huai-Ling Annie Hsu

Andrej Maroz

Kendall Marie Carlin

Gareth Adrian Prosser

Sophie Phillipa Syddall

The invention relates generally to bacterial nitroreductase enzymes and methods of use thereof: more particularly, although not exclusively, the enzymes have use in non-invasive imaging techniques, monitoring of therapeutic cell populations and gene-directed enzyme prodrug therapy. The invention also relates to the use of bacterial nitroreductase enzymes in radioimaging and/or ablation of biological agents and to compositions of use in such methods.

Bacterial nitroreductase enzymes and methods relating thereto

The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.

Prodrugs and methods of use thereof

The invention provides kinase inhibitors of Formula I:  Also provided are reductive prodrugs, comprising a kinase inhibitor as defined above and a reductive trigger linked directly or indirectly to a nitrogen of the kinase inhibitor. Further provided are pharmaceutical compositions, comprising the kinase inhibitors or the prodrugs, and the use of such compositions in therapy, in particular for treating cancer.

Kinase inhibitors, prodrug forms thereof and their use in therapy

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Auckland, New Zealand

Alexandra Marie Mowday