Bristol-myers Squibb Compnay

Alexandra Holubec

Jeffrey A Robl

Lawrence G Hamann

David John Augeri

James Clifford Sutton

Tammy C Wang

James J Li

Yingzhi Bi

Chong-qing Sun

Ligaya Simpkins

Yan-Ting Huang

Uwe D Treuner

Gregory S Bisacchi

Peter W Glunz

George C Morton

Xiaojun Zhang

E Scott Priestley

There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.

Bicyclic modulators of androgen receptor function

The invention provides compounds according to formula I  Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.

Compounds having the formula (I), or a stereoisomer or pharmaceutically-acceptable salt, or hydrate thereof, are useful as factor VIIa inhibitors, wherein X is &#x2014;NRS(O)R; W is hydrogen or &#x2014;(CRR)W; Wis hydrogen or a bond with R; Z is a-membered heteroaryl group, a five to six membered heterocyclo or cycloalkyl group, atomembered bicyclic aryl or heteroaryl, or a six membered aryl or heteroaryl, and R, R, R, R, R, and Rare as defined in the specification.

Phenylglycine derivatives useful as serine protease inhibitors

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Yardley, PA, United States of America

Alexandra Holubec