Ctxt Pty Limited

Cancer Therapeutics Crc Pty Limited

Alexandra Elizabeth Stupple

Paul Anthony Stupple

Scott Raymond Walker

Michelle Ang Camerino

Richard Charles Foitzik

Ylva Elisabet Bergman

Ian Peter Holmes

Gillian Elizabeth Lunniss

Wilhelmus Johannes Antonius Kersten

Helen Rachel Lagiakos

Jo-Anne Pinson

A compound of formula (I) wherein: n is 1 or 2; p is 0 or 1; R, R, Rand Rare independently selected from H, halo, methyl and methoxy; Rand Rare independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CHOH; Rand Rare independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CHOH; Ris H or Me; Rand Rare independently selected from H and Me; Ris either H or Me; Rand Rare independently selected from H and Me; X is either N or CH; Ris selected from H and Calkyl; (a) one of R, R, R, and Ris selected from H, halo, Calkyl, Calkoxy, NHCalkyl; (b) another of R, R, Rand Ris selected from H, Calkyl, Cfluoroalkyl, Ccycloalkyl, Cheteroaryl, Cheteroaryl methyl, Cheterocyclyl, Cheterocyclyl methyl, phenyl, benzyl, halo, amido, amidomethyl, acylamido, acylamidomethyl, Calkyl ester, Calkyl ester methyl, Calkyl carbamoyl, Calkyl carbamoyl methyl, Calkylacyl, Calkylacyl methyl, phenylcarbonyl, carboxy, carboxymethyl, ether, amino, amino methyl, sulfonamido, sulfonamino, sulfone, sulfoxide, nitrile and nitrilemethyl; (c) the others of R, R, Rand Rare H. 

Tetrahydroisoquinolines as PRMT5 inhibitors

Substituted benzimidazole and 3H-imidazo[4,5-b]pyridines or formula I: where X and Y respectively are selected from: (i) N and N; and (ii) N and CR; Ais selected from: a Cheteroarylene group, containing 2 or 3 ring heteroatoms, where the bonds to L1 and the core are &#x3b2; to one another; Lis selected from: (i)&#x2014;O&#x2014;CH&#x2014;; (ii)&#x2014;CH&#x2014;O&#x2014;; (iii)&#x2014;C(&#x2550;O)&#x2014;NH&#x2014;; (iv)&#x2014;CH(OH)&#x2014;; (v)&#x2014;CH&#x2014;NH&#x2014;C(&#x2550;O)&#x2014;; (vi)&#x2014;S&#x2014;CH&#x2014;; (vii)&#x2014;CH&#x2014;S&#x2014;; (viii)&#x2014;CH&#x2014;; and (ix)&#x2014;CH(CH)&#x2014;O&#x2014;; A1 is phenyl, optionally substituted by F or CF; their use as pharmaceuticals, and in particular, in treating cancer and hemoglobinopathies. 

2-(hetero)aryl-benzimidazole and imidazopyridine derivatives as inhibitors of asparagime emethyl transferase

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Victoria, Australia

Alexandra Elizabeth Stupple