Dornier Medtech Systems, Gmbh

Heeschen, Christopher

Aicher, Alexandra

Zeiher, Andreas Michael

Dimmeler, Stefanie

Alexandra Aicher

Christopher Heeschen

Stefanie Dimmeler

Andreas Michael Zeiher

Harald Eizenhofer

Harald Eizenhöfer

Andreas Lutz

Improving cell therapy and tissue regeneration in a patient suffering from a cardiovascular or a neurological disease by treating a tissue of the patient with shock waves and/or applying to the patient a therapeutically effective amount of stem cells and/or progenitor cells. Such treatment increases expression of chemoattractants, pro-angiogenic factors, and pro-survival factors. The chemoattractants can be, for example, vascular endothelial growth factor (VEGF) or stromal cell derived factor 1 (SDF-1). For example, the treated tissue can be located in the patient's heart or in a skeletal muscle of the patient, and the shock waves can be extracorporeal shock waves (ESW) or intracorporeal shock waves. The cardiovascular disease can have an ischemic or non-ischemic etiology. For example, the cardiovascular disease can be a myocardial infarction, ischemic cardiomyopathy, or a dilatative cardiomyopathy. For example, the neurological disease can be a peripheral neuropathy or neuropathic pain.

Methods for improving cell therapy and tissue regeneration in patients with cardiovascular diseases by means of shockwaves

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Frankfurt-am-Main, Germany

Alexandra Aicher