Somnarus Inc.

Koninklijke Philips Corporation N.V.

Imi International Medical Innovations, Inc.

Imi International Medical Iinnovations, Inc.

Alexandr Sergeivich Parfenov

Maria A Parfenova

Yuri P Zobnin

Nikolay V Konstantinov

Yuri Michaelovich Lopukhin

Alexander Michaelovich Maleev

Yevgeney Borisovich Bablyuk

Alxandr B Rabovski

Ivan Alexandrovich Kochetov

Yury Michaelovich Lopukhin

Yuri Zobnin

A sleep apnea diagnostic system includes a housing that is configured to be attached to near the nose of a patient's face to sense physiological information of a patient. The housing includes sensors to sense the physiological information. The physiological information may be, for example, air flow through the nose or the mouth or both. The physiological information further may be, for example, blood volume. The sleep apnea diagnostic system includes at least one processor in the housing or external to the housing or both to analyze the physiological information to determine whether the patient has experienced irregular or abnormal respiratory activity and to detect respiratory effort. The analysis may be real time or delayed.

Methods for detection of respiratory effort and sleep apnea monitoring devices

A multilayer analytical element for determining a level of an analyte on a substrate and adapted for use with hydrogen peroxide and an affinity-enzymatic compound of formula A-C-B, wherein A is a detecting agent having affinity for the analyte, B is an enzymatic visualizing agent consisting of peroxidase and C is a binding agent linking the detecting and visualizing agents together. The multilayer analytical element of the invention comprises a solid support and a hydrophilic layer thereon, the hydrophilic layer being formed of gelatin, polyvinyl alcohol or a mixture thereof and containing a developing agent and a hydrophobic color-producing agent in a total amount of 5 to 30 weight %, the developing agent and the color-producing agent being present in a weight ratio of 1:0.3 to 1:3.0. The developing agent is capable of undergoing oxidation by the hydrogen peroxide in the presence of the peroxidase bound via the binding and detecting agents to the analyte on the substrate, whereby the developing agent in oxidized form reacts with the color-producing agent to form a colored product having a color indicative of the level of analyte.

Method for determining analyte level

A method of determining skin tissue cholesterol includes preparing a section of skin surface, applying a dosed amount of an enzyme-containing mixture onto the skin, exposing, evaluating the concentration of cholesterol in a reaction solution and calculating the concentration of skin cholesterol, wherein the area of contact of the skin with the mixture is limited on the section of the skin surface by means of a sealing vessel without a bottom with a base fixed on the skin, a mixture comprising 2.0-2.5 units of cholesteroloxidase, 0.04-0.06% by weight of sodium dezoxycholate, 0.1-0.2.% by weight of 3-(dodecyl-dimethyl-ammonium)-propanesulfonate in a buffer solution with pH&equals;6.8 is used as the mixture, evaluating the concentration of cholesterol in the reaction solution is carried out by measuring the level of hydrogen peroxide. Measurements of the level of hydrogen peroxide may be carried out by immersing an electrochemical sensor or a colorimetric indicator in the reaction solution.

Method of determining skin tissue cholesterol

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Moscow, Russia

Alexandr Sergeivich Parfenov