Concortis Biosystems, Corp.

Sorrento Therapeutics, Inc.

Alexander Wilhelm Chucholowski

Zhenwei Miao

Tong Zhu

Yufeng Hong

Gang Chen

Hong Zhang

Alisher B Khasanov

In one aspect, an active agent-conjugate, methods of preparing the active agent-conjugate, and uses thereof is provided.

Drug-conjugates, conjugation methods, and uses thereof

There is disclosed an improved ADC (antibody drug conjugate) type composition having at least two different drug payloads conjugated to a single targeting protein. More specifically, the present disclosure attaches a first drug conjugate to a dual Cysteine residue on a targeting protein and a second drug conjugate with a different drug to a Lys residue on the targeting protein.

Drug-conjugates with a targeting molecule and two different drugs

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Poway, CA, United States of America

Alexander Wilhelm Chucholowski